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Carsten Lindschau
Researcher at Hannover Medical School
Publications - 80
Citations - 7210
Carsten Lindschau is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Protein kinase C & Vascular smooth muscle. The author has an hindex of 44, co-authored 80 publications receiving 6921 citations. Previous affiliations of Carsten Lindschau include Charité & Free University of Berlin.
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Journal ArticleDOI
Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice
Marek Drab,Paul Verkade,Marlies Elger,Michael Kasper,Matthias Lohn,Matthias Lohn,Birgit Lauterbach,Birgit Lauterbach,Jan Menne,Carsten Lindschau,Carsten Lindschau,Fanny Mende,Friedrich C. Luft,Andreas Schedl,Hermann Haller,Teymuras V. Kurzchalia +15 more
TL;DR: By targeted disruption of caveolin-1, the main protein component of caveolae, mice that lacked Caveolae were generated, causing aberrations in endothelium-dependent relaxation, contractility, and maintenance of myogenic tone and indicating a fundamental role in organizing multiple signaling pathways in the cell.
Journal ArticleDOI
Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor.
Gerd Wallukat,Volker Homuth,Thorsten Fischer,Carsten Lindschau,Björn Horstkamp,Axel Jüpner,Evi Baur,Eberhard Nissen,Klaus Vetter,Dajana Neichel,Joachim W. Dudenhausen,Hermann Haller,Friedrich C. Luft +12 more
TL;DR: It is suggested that preeclamptic patients develop stimulatory autoantibodies against the second extracellular AT1 receptor loop, which appears to be PKC-mediated and may participate in the angiotensin II-induced vascular lesions in these patients.
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From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Marek Drab,Hermann Haller,Rostislav Bychkov,Bettina Erdmann,Carsten Lindschau,Hannelore Haase,Ingo Morano,Friedrich C. Luft,Anna M. Wobus +8 more
TL;DR: A retinoic acid + db‐cAMP‐inducible embryonic stem cell model of in vitro vasculogenesis and ES cell‐derived cells expressing VSMC‐specific MHC and functional VSMC properties may be a suitable system to study mechanisms of VSMC differentiation.
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Aldosterone Potentiates Angiotensin II-Induced Signaling in Vascular Smooth Muscle Cells
Istvan Mazak,Anette Fiebeler,Dominik N. Müller,Joon-Keun Park,Erdenechimeg Shagdarsuren,Carsten Lindschau,Ralf Dechend,Christiane Viedt,Bernhard Pilz,Hermann Haller,Friedrich C. Luft +10 more
TL;DR: Oxygen radicals, the MR, and the EGFR play a role in early signaling induced by Ang II and Ald in VSMCs and may help explain the effects of MR blockade on Ang II–induced end-organ damage in vivo.
Journal ArticleDOI
High Glucose Concentrations Increase Endothelial Cell Permeability via Activation of Protein Kinase Cα
Albrecht Hempel,Christian Maasch,Ute Heintze,Carsten Lindschau,Rainer Dietz,Friedrich C. Luft,Hermann Haller +6 more
TL;DR: It is concluded that an increase in extracellular glucose leads to a rapid dose-dependent increase in endothelial cell permeability via the activiation of PKC and that this effect is mediated by the PKC isoform alpha.