Gergana Dobreva

TL;DR: Satb2 functions as a repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex and binds directly to regulatory regions of C Tip2 and induces changes in chromatin structure.

TL;DR: It is shown that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage and directly interacts with and enhances the activity of both Runx2 and ATF4, transcription factors that regulate osteOBlast differentiation.

TL;DR: A novel cell type-specific MAR-binding protein is characterized, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression and activation potential and association with endogenous MARs in vivo.

TL;DR: It is shown that cortical neurons deploy a complex genetic switch that uses mutual repression to produce subcortical or callosal projections and that Satb2 and Fezf2 regulate two disease-related genes, Auts2 (Autistic Susceptibility Gene2) and Bhlhb5 (mutated in Hereditary Spastic Paraplegia), providing a molecular handle to investigate circuit disorders in neurodevelopmental diseases.

TL;DR: It is demonstrated that TIF‐IA interacts with Pol I in the absence of template DNA, augments Pol I transcription in vivo and rescues transcription in extracts from growth‐arrested cells in vitro.