G
Gerhard Behre
Researcher at Center for Cell and Gene Therapy
Publications - 73
Citations - 4477
Gerhard Behre is an academic researcher from Center for Cell and Gene Therapy. The author has contributed to research in topics: Transplantation & Myeloid leukemia. The author has an hindex of 28, co-authored 67 publications receiving 4229 citations. Previous affiliations of Gerhard Behre include Ludwig Maximilian University of Munich & Harvard University.
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Journal ArticleDOI
Dominant-negative mutations of CEBPA , encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
Thomas Pabst,Beatrice U. Mueller,Pu Zhang,Hanna S. Radomska,Sailaja Narravula,Susanne Schnittger,Gerhard Behre,Wolfgang Hiddemann,Daniel G. Tenen +8 more
TL;DR: This is the first report of CEBPA mutations in human neoplasia, and such mutations are likely to induce the differentiation block found in AML.
Journal ArticleDOI
Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1.
Pu Zhang,Gerhard Behre,Jing Pan,Atsushi Iwama,Nawarat Wara-aswapati,Hanna S. Radomska,Philip E. Auron,Daniel G. Tenen,Zijie Sun +8 more
TL;DR: Interactions between PU.1 and GATA proteins play a critical role in the decision of stem cells to commit to erythroid vs. myeloid lineages, suggesting that normal hematopoietic lineage development is under threat.
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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.
Thomas Pabst,Beatrice U. Mueller,Nari Harakawa,Claudia Schoch,Torsten Haferlach,Gerhard Behre,Wolfgang Hiddemann,Dong-Er Zhang,Daniel G. Tenen +8 more
TL;DR: It is suggested that restoring C/EBPα expression will have therapeutic implications in RUNX1–CBF2T1-positive leukemias and Cebpa knockout mice exhibit an early block in maturation.
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The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
Rajani Kanth Vangala,Marion S. Heiss-Neumann,Marion S. Heiss-Neumann,Janki Rangatia,Janki Rangatia,Sheo M. Singh,Sheo M. Singh,Claudia Schoch,Claudia Schoch,Daniel G. Tenen,Daniel G. Tenen,Wolfgang Hiddemann,Wolfgang Hiddemann,Gerhard Behre,Gerhard Behre +14 more
TL;DR: PU.1 is down-regulated by AML1-ETO in t(8;21) myeloid leukemia, whereas overexpression of PU.1 restores normal differentiation.
Journal ArticleDOI
Heterozygous PU.1 mutations are associated with acute myeloid leukemia
Beatrice U. Mueller,Thomas Pabst,Motomi Osato,Norio Asou,Lisa M. Johansen,Mark D. Minden,Gerhard Behre,Wolfgang Hiddemann,Yoshiaki Ito,Daniel G. Tenen +9 more
TL;DR: The first report of mutations in the PU.1 gene in human neoplasia is reported and suggests that disruption ofPU.1 function contributes to the block in differentiation found in AML patients.