S
Sailaja Narravula
Researcher at Brigham and Women's Hospital
Publications - 7
Citations - 1677
Sailaja Narravula is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Transcription factor & Barrier function. The author has an hindex of 6, co-authored 7 publications receiving 1553 citations. Previous affiliations of Sailaja Narravula include Yale University & University of California, Los Angeles.
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Journal ArticleDOI
Dominant-negative mutations of CEBPA , encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia
Thomas Pabst,Beatrice U. Mueller,Pu Zhang,Hanna S. Radomska,Sailaja Narravula,Susanne Schnittger,Gerhard Behre,Wolfgang Hiddemann,Daniel G. Tenen +8 more
TL;DR: This is the first report of CEBPA mutations in human neoplasia, and such mutations are likely to induce the differentiation block found in AML.
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Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia
Glenn T. Furuta,Jerrold R. Turner,Cormac T. Taylor,Robert M. Hershberg,Katrina M. Comerford,Sailaja Narravula,Daniel K. Podolsky,Sean P. Colgan +7 more
TL;DR: HIF-1–dependent induction of ITF may provide an adaptive link for maintenance of barrier function during hypoxia, and help to protect epithelial barrier during episodes of intestinalHypoxia-elicited increases in intestinal permeability in ITF null mice are revealed.
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Hypoxia-Inducible Factor 1-Mediated Inhibition of Peroxisome Proliferator-Activated Receptor α Expression During Hypoxia
Sailaja Narravula,Sean P. Colgan +1 more
TL;DR: Results indicate that Hif-1-dependent down-regulation of PPAR-α may provide an adaptive response to proinflammatory stimuli during cellular hypoxia, and provide an example of a down-regulatory pathway mediated by HIF-1.
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Regulation of Endothelial CD73 by Adenosine: Paracrine Pathway for Enhanced Endothelial Barrier Function
TL;DR: The results provide an example of transcriptional induction of enzyme (CD73) by enzymatic product (adenosine) and define a paracrine pathway for the regulated expression of vascular endothelial CD73 and barrier function.
Journal ArticleDOI
A nuclear factor Y (NFY) site positively regulates the human CD34 stem cell gene.
Hanna S. Radomska,Anne B. Satterthwaite,Anne B. Satterthwaite,Anne B. Satterthwaite,Natalie Taranenko,Natalie Taranenko,Natalie Taranenko,Sailaja Narravula,Sailaja Narravula,Sailaja Narravula,Diane S. Krause,Diane S. Krause,Diane S. Krause,Daniel G. Tenen +13 more
TL;DR: The results indicate that the functional similarities between the human and murine CD34 5' UTRs are achieved through different molecular mechanism(s).