G
Gerhard Jahn
Researcher at University of Tübingen
Publications - 221
Citations - 12574
Gerhard Jahn is an academic researcher from University of Tübingen. The author has contributed to research in topics: Human cytomegalovirus & Antigen. The author has an hindex of 54, co-authored 221 publications receiving 12080 citations. Previous affiliations of Gerhard Jahn include University of Erlangen-Nuremberg & Robert Koch Institute.
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Journal ArticleDOI
A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus
Michael Boshart,Frank Weber,Gerhard Jahn,Karoline Dorsch-Häsler,Bernhard Fleckenstein,Walter Schaffner +5 more
TL;DR: The HCMV enhancer, which seems to have little cell type or species preference, is severalfold more active than the SV40 enhancers, a property that makes it a useful component of eukaryotic expression vectors.
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Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy.
Hermann Einsele,Eddy Roosnek,Nathalie Rufer,Christian Sinzger,Susanne Riegler,Jürgen Löffler,Ulrich Grigoleit,Arnaud Moris,Hans-Georg Rammensee,Lothar Kanz,Annette Kleihauer,Friederike Frank,Gerhard Jahn,Holger Hebart +13 more
TL;DR: Anti-CMV cellular therapy was successful in 5 of 7 patients, whereas in 2 of7 patients, who received an intensified immune suppression at the time of or after T-cell therapy, only transient reductions in virus load were obtained.
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Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation
Hermann Einsele,Gerhard Ehninger,Holger Hebart,Knut M. Wittkowski,Schuler U,Gerhard Jahn,P. Mackes,M. Herter,Thomas Klingebiel,Jürgen Löffler,Silvia Wagner,Claudia A. Müller +11 more
TL;DR: Preemptive therapy based on more sensitive detection methods such as the PCR assay reduces the incidence of CMV disease and CMV-related mortality and allows reduction of the duration and side effects of antiviral therapy.
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Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding
TL;DR: The proportion of cytomegalovirus reactivation during lactation almost equals maternal seroprevalence, which has been underestimated and may be associated with a symptomatic infection.
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Fibroblasts, epithelial-cells, endothelial-cells and smooth-muscle cells are major targets of human cytomegalovirus-infection in lung and gastrointestinal tissues
TL;DR: The analysis of the distribution of infected cells in tissue supported the hypothesis that endothelial cells and monocytes/macrophages may play a crucial role in the haematogenous spread of HCMV; in contrast, fibroblasts, smooth muscle cells and epithelial cells may form the cell populations important for the multiplication and spread of the virus in infected tissues.