Ghita C.-M. Falck

TL;DR: Understanding the mechanistic origin and contents of MN is essential for the proper use of this cytogenetic end-point in biomarker studies, genotoxicity testing and risk assessment, where differences in MN frequencies between exposed subjects and referents are expected to be small.

TL;DR: The results suggest that both CNTs and GNFs are genotoxic in human bronchial epithelial BEAS 2B cells in vitro, and this activity may be due to the fibrous nature of these carbon nanomaterials with a possible contribution by catalyst metals present in the materials.

TL;DR: The studies in human bronchial epithelial BEAS 2B cells showed that uncoated nanosized anatase TiO2 and fine rutileTiO2 are more efficient than SiO 2-coated Nanosized rutiles TiO 2 in inducing DNA damage, whereas only nanosize anatase is able to slightly induce micronuclei.

TL;DR: It is crucial to identify those ENm that may cause occupational health and safety risks from those ENM which are innocent, hence allowing prioritization of regulatory and preventive actions at workplaces at national, regional and global levels.

TL;DR: It is suggested that micronuclei in binucleate lymphocytes primarily derive from lagging chromosomes and terminal acentric fragments during mitosis, and that nuclear buds and micron nuclei have partly different mechanistic origin.