G
Gian Pio Sorice
Researcher at Catholic University of the Sacred Heart
Publications - 42
Citations - 1656
Gian Pio Sorice is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Insulin resistance & Diabetes mellitus. The author has an hindex of 19, co-authored 31 publications receiving 1347 citations. Previous affiliations of Gian Pio Sorice include Agostino Gemelli University Polyclinic & The Catholic University of America.
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Journal ArticleDOI
Blockade of receptor activator of nuclear factor-κB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus
Stefan Kiechl,Jürgen Wittmann,Andrea Giaccari,Michael Knoflach,Peter Willeit,Aline Bozec,Alexander R. Moschen,Giovanna Muscogiuri,Gian Pio Sorice,Trayana Kireva,Monika Summerer,Stefan Wirtz,Julia Luther,Dirk Mielenz,Ulrike Billmeier,Georg Egger,Agnes Mayr,Friedrich Oberhollenzer,Florian Kronenberg,Michael Orthofer,Josef M. Penninger,James B. Meigs,Enzo Bonora,Herbert Tilg,Johann Willeit,Georg Schett +25 more
TL;DR: Evidence is provided for a role of RANKL signaling in the pathogenesis of T2DM and if so, translation to the clinic may be feasible given current pharmacological strategies to lower RankL activity to treat osteoporosis.
Journal ArticleDOI
Insulin Resistance Alters Islet Morphology in Nondiabetic Humans
Teresa Mezza,Giovanna Muscogiuri,Gian Pio Sorice,Gennaro Clemente,Jiang Hu,Alfredo Pontecorvi,Jens J. Holst,Andrea Giaccari,Rohit N. Kulkarni +8 more
TL;DR: The data in this series of studies suggest that neogenesis from duct cells and transdifferentiation of α-cells are potential contributors to the β-cell compensatory response to insulin resistance in the absence of overt diabetes.
Journal ArticleDOI
25-Hydroxyvitamin D Concentration Correlates With Insulin-Sensitivity and BMI in Obesity
Giovanna Muscogiuri,Gian Pio Sorice,Annamaria Prioletta,Caterina Policola,Silvia Della Casa,Alfredo Pontecorvi,Andrea Giaccari +6 more
TL;DR: It is suggested that there is no cause–effect relationship between vitamin D and insulin‐sensitivity in obesity, and both low 25(OH)D concentration and insulin-resistance appear to be dependent on the increased body size.
Journal ArticleDOI
Can vitamin D deficiency cause diabetes and cardiovascular diseases? Present evidence and future perspectives.
Giovanna Muscogiuri,Gian Pio Sorice,R. Ajjan,Teresa Mezza,Stefan Pilz,Annamaria Prioletta,Robert Scragg,S.L. Volpe,Miles D. Witham,Andrea Giaccari +9 more
TL;DR: Clinical retrospective and prospective observational studies linking vitamin D levels with cardio-metabolic risk factors and vascular outcome are summarized and various randomised controlled trials (RCTs) investigating the effects of vitamin D supplementation on surrogate markers of cardiovascular risk are reviewed.
Journal ArticleDOI
Vitamin D Deficiency: A New Risk Factor for Type 2 Diabetes
Teresa Mezza,Giovanna Muscogiuri,Gian Pio Sorice,Annamaria Prioletta,Enrica Salomone,Alfredo Pontecorvi,Andrea Giaccari +6 more
TL;DR: The circumstances leading to vitamin D deficiency and how such a deficiency can eventually independently affect insulin sensitivity are reviewed, leaving open the possibility that vitamin D and diabetes are not related at all.