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Gianluigi Lichinchi
Researcher at University of California, San Diego
Publications - 10
Citations - 1562
Gianluigi Lichinchi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: RNA & Messenger RNA. The author has an hindex of 8, co-authored 10 publications receiving 1213 citations. Previous affiliations of Gianluigi Lichinchi include Sanford-Burnham Institute for Medical Research & Discovery Institute.
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Journal ArticleDOI
Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.
Jason Dang,Shashi Kant Tiwari,Gianluigi Lichinchi,Yue Qin,Veena S. Patil,Alexey Eroshkin,Tariq M. Rana +6 more
TL;DR: It is shown that a prototype strain of ZIKV, MR766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number.
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Dynamics of the human and viral m 6 A RNA methylomes during HIV-1 infection of T cells
Gianluigi Lichinchi,Gianluigi Lichinchi,Shang Gao,Yogesh Saletore,Gwendolyn Gonzalez,Vikas Bansal,Yinsheng Wang,Christopher E. Mason,Tariq M. Rana,Tariq M. Rana +9 more
TL;DR: It is shown that viral infection triggers a massive increase in m6A in both host and viral mRNAs, which identifies a new mechanism for the control of HIV-1 replication and its interaction with the host immune system.
Journal ArticleDOI
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection.
Gianluigi Lichinchi,Gianluigi Lichinchi,Boxuan Simen Zhao,Boxuan Simen Zhao,Yinga Wu,Yinga Wu,Zhike Lu,Zhike Lu,Yue Qin,Chuan He,Chuan He,Tariq M. Rana,Tariq M. Rana +12 more
TL;DR: It is reported that ZIKV infection affects viral and human RNAs by altering the topology and function of N6-adenosine methylation (m6A), a modification affecting RNA structure and function.
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1,2,3-Triazoles as Amide Bioisosteres: Discovery of a New Class of Potent HIV-1 Vif Antagonists
Idrees Mohammed,Indrasena Reddy Kummetha,Gatikrushna Singh,Natalia Sharova,Gianluigi Lichinchi,Gianluigi Lichinchi,Jason Dang,Mario Stevenson,Tariq M. Rana,Tariq M. Rana +9 more
TL;DR: RN-18 based viral infectivity factor (Vif), Vif antagonists reduce viral infectivities by rescuing APOBEC3G (A3G) expression and enhancing A3G-dependent Vif degradation and identifying several potent HIV-1 inhibitors from a 1d based library.
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Genome-Wide CRISPR Screen for Essential Cell Growth Mediators in Mutant KRAS Colorectal Cancers.
Edwin Yau,Indrasena Reddy Kummetha,Gianluigi Lichinchi,Rachel Tang,Yunlin Zhang,Tariq M. Rana +5 more
TL;DR: This study exploited the power of the CRISPR-Cas9 system to identify genes affecting the tumor xenograft growth of human mutant KRAS (KRASMUT) colorectal cancers, and defined a novel targetable set of therapeutic targets for KRasMUT tumors.