G
Gianrico Farrugia
Researcher at Mayo Clinic
Publications - 493
Citations - 21305
Gianrico Farrugia is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Interstitial cell of Cajal & Gastroparesis. The author has an hindex of 71, co-authored 450 publications receiving 17810 citations. Previous affiliations of Gianrico Farrugia include Boston University & State University of New York System.
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Journal ArticleDOI
Neural autoantibody profile of primary achalasia.
TL;DR: The serum profile of autoantibodies suggests an autoimmune basis for a subset of primary achalasia, and specifically targeting neuronal, glial, and muscle autoantigens.
Journal ArticleDOI
Carbon monoxide activates human intestinal smooth muscle L-type Ca2+ channels through a nitric oxide-dependent mechanism.
Inja Lim,Simon J. Gibbons,Gregory L Lyford,Steven M. Miller,Peter R. Strege,Michael G. Sarr,Suvro Chatterjee,Joseph H. Szurszewski,Vijay H. Shah,Gianrico Farrugia +9 more
TL;DR: The data suggest that exogenous CO can activate native and heterologously expressed intestinal L-type Ca(2+) channels through a pathway that involves activation of NOS, increased NO, and cGMP levels, but not PKG, although the pathway appears to involve PKA.
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A Mutation in Telethonin Alters Nav1.5 Function
Amelia Mazzone,Peter R. Strege,David J. Tester,Cheryl E. Bernard,Georgine Faulkner,Roberto De Giorgio,Jonathan C. Makielski,Vincenzo Stanghellini,Simon J. Gibbons,Michael J. Ackerman,Gianrico Farrugia +10 more
TL;DR: Results suggest a new role for telethonin, namely that teleth onin is a sodium channel-interacting protein, which can alter Nav1.5 kinetics and may play a role in intestinal pseudo-obstruction.
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Implementing individualized medicine into the medical practice
Konstantinos N. Lazaridis,Tammy M. McAllister,Dusica Babovic-Vuksanovic,Scott A. Beck,Mitesh J. Borad,Alan H. Bryce,Asher Chanan-Khan,Matthew J. Ferber,Rafael Fonseca,Kiley J. Johnson,Eric W. Klee,Noralane M. Lindor,Jennifer B. McCormick,Robert R. McWilliams,Alexander S. Parker,Douglas L. Riegert-Johnson,Carolyn R. Rohrer Vitek,Kimberly A. Schahl,Cloann G. Schultz,Keith Stewart,George C Then,Eric D. Wieben,Gianrico Farrugia +22 more
TL;DR: This review describes the approach taken by one institution to further individualize medicine by offering, executing and interpreting whole exome sequencing on a clinical basis through an enterprise‐wide, standalone individualized medicine clinic.
Journal ArticleDOI
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation
Roman E. Perri,Daniel Langer,Suvro Chatterjee,Simon J. Gibbons,Jay Gadgil,Sheng Cao,Gianrico Farrugia,Vijay H. Shah +7 more
TL;DR: It is demonstrated that NO affects HSC through cGMP-dependent and -independent pathways, and activating targets downstream from NO-cGMP in activated HSC may represent a novel therapeutic target for portal hypertension.