G
Gianrico Farrugia
Researcher at Mayo Clinic
Publications - 493
Citations - 21305
Gianrico Farrugia is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Interstitial cell of Cajal & Gastroparesis. The author has an hindex of 71, co-authored 450 publications receiving 17810 citations. Previous affiliations of Gianrico Farrugia include Boston University & State University of New York System.
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Journal ArticleDOI
Marijuana Use in Patients with Symptoms of Gastroparesis: Prevalence, Patient Characteristics, and Perceived Benefit
Henry P. Parkman,Emily P. Sharkey,Linda Nguyen,Katherine P. Yates,Thomas L. Abell,William L. Hasler,William J. Snape,John Clarke,Ron Schey,Kenneth L. Koch,Braden Kuo,Richard W McCallum,Irene Sarosiek,Madhusudan Grover,Gianrico Farrugia,James Tonascia,Pankaj J. Pasricha +16 more
TL;DR: Patients with severe nausea and abdominal pain were more likely to use marijuana and perceive it to be beneficial for their symptoms, while a subset of patients with symptoms of Gp use marijuana.
Journal ArticleDOI
Patch-clamp recordings of membrane currents evoked during natural synaptic activity in sympathetic neurons
TL;DR: The results suggest that colonic afferent nerve fibres activate in the mouse superior mesenteric ganglion neurons a few populations of the postsynaptic nicotinic acetylcholine receptors with different channel kinetics, which are characterized by a lack of voltage sensitivity within -70 to -110 mV membrane potential range, except those with comparatively slow channel kin mechanics which are possibly blocked by membrane hyperpolarization.
Journal ArticleDOI
Serotonergic modulation of murine fundic tone.
Lin Xue,Michael Camilleri,G. Richard Locke,Jan A. J. Schuurkes,Ann Meulemans,Bernard Coulie,Joseph H. Szurszewski,Gianrico Farrugia +7 more
TL;DR: The aim of this study was to determine the role of serotonin (5-HT) and 5-HT receptors in modulating fundic smooth muscle tone through a balance of excitatory and inhibitory input.
Journal ArticleDOI
Gut Microbial β-Glucuronidases Regulate Host Luminal Proteases and are depleted in Irritable Bowel Syndrome
Adam Edwinson,Lu Yang,Stephanie A. Peters,Nikita Hanning,Patricio Jeraldo,Pratik D. Jagtap,Joshua B. Simpson,Tzu-Yi Yang,Praveen Kumar,Subina Mehta,Asha Nair,Margaret K. Breen-Lyles,Lakshmikanth L. Chikkamenahalli,Rondell P. Graham,Benedicte Y. De Winter,Robin Patel,Surendra Dasari,Purna C. Kashyap,Timothy J. Griffin,Jun Chen,Gianrico Farrugia,Matthew R. Redinbo,Madhusudan Grover +22 more
TL;DR: This paper showed that members of the gut microbiota suppress intestinal proteolytic activity through production of unconjugated bilirubin, which occurs via microbial β-glucuronidase-mediated conversion of bilirus conjugates.
Journal ArticleDOI
Coupling and innervation patterns of interstitial cells of Cajal in the deep muscular plexus of the guinea-pig
TL;DR: Direct evidence for functional coupling within the ICC‐DMP network, and between this network and cells of the outer circular muscle layer is provided and it is shown that coupling can be affected by pH.