G
Gil Levkowitz
Researcher at Weizmann Institute of Science
Publications - 74
Citations - 7071
Gil Levkowitz is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Zebrafish & Receptor. The author has an hindex of 30, co-authored 66 publications receiving 6624 citations. Previous affiliations of Gil Levkowitz include Tel Aviv University.
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Journal ArticleDOI
A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor.
E Tzahar,Hadassa Waterman,Xiaomei Chen,Gil Levkowitz,Devarajan Karunagaran,Sara Lavi,B J Ratzkin,Yosef Yarden +7 more
TL;DR: The observed superior ability of ErbB-2 to form heterodimers, in conjunction with its uniquely high basal tyrosine kinase activity, may explain why Erb B-2 overexpression is associated with poor prognosis.
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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Gil Levkowitz,Hadassa Waterman,Seth A. Ettenberg,Menachem Katz,Alexander Y. Tsygankov,Iris Alroy,Sara Lavi,Kazuhiro Iwai,Yuval Reiss,Aaron Ciechanover,Stanley Lipkowitz,Yosef Yarden +11 more
TL;DR: This study identifies Cbl proteins as components of the ubiquitin ligation machinery and implies that they similarly suppress many other signaling pathways.
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c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
Gil Levkowitz,Hadassa Waterman,Eli Zamir,Zvi Kam,Shlomo Oved,Wallace Y. Langdon,Laura Beguinot,Benjamin Geiger,Yosef Yarden +8 more
TL;DR: An endosomal sorting machinery capable of controlling the fate, and, hence, signaling potency, of growth factor receptors is revealed.
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Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.
Ronit Pinkas-Kramarski,Lior Soussan,Hadassa Waterman,Gil Levkowitz,Iris Alroy,Leah N. Klapper,Sara Lavi,Rony Seger,B J Ratzkin,Michael Sela,Yosef Yarden +10 more
TL;DR: It is conceivable that combinatorial receptor interactions diversify signal transduction and confer double regulation, in cis and in trans, of the superior mitogenic activity of the kinase‐defective ErbB‐3.
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The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor
TL;DR: It is demonstrated that the RING type zinc finger of c-Cbl is essential for ubiquitination and subsequent desensitization of EGFR and plays an essential direct role in ubiquitin ligation.