M
Menachem Katz
Researcher at Rockefeller University
Publications - 22
Citations - 4622
Menachem Katz is an academic researcher from Rockefeller University. The author has contributed to research in topics: Signal transduction & Ubiquitin ligase. The author has an hindex of 17, co-authored 21 publications receiving 4394 citations. Previous affiliations of Menachem Katz include Weizmann Institute of Science & Columbia University.
Papers
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Journal ArticleDOI
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.
Gil Levkowitz,Hadassa Waterman,Seth A. Ettenberg,Menachem Katz,Alexander Y. Tsygankov,Iris Alroy,Sara Lavi,Kazuhiro Iwai,Yuval Reiss,Aaron Ciechanover,Stanley Lipkowitz,Yosef Yarden +11 more
TL;DR: This study identifies Cbl proteins as components of the ubiquitin ligation machinery and implies that they similarly suppress many other signaling pathways.
Journal ArticleDOI
Dynamics and segregation of cell-matrix adhesions in cultured fibroblasts
Eli Zamir,Menachem Katz,Yehudit Posen,Noam Erez,Kenneth M. Yamada,Ben-Zion Katz,Shin Lin,Diane C. Lin,Alexander D. Bershadsky,Zvi Kam,Benjamin Geiger +10 more
TL;DR: A dynamic model for the regulation of cell–matrix adhesions and for transitions between focal contacts and fibrillar adhesion is proposed, with the ability of the matrix to deform functioning as a mechanical switch.
Journal ArticleDOI
A module of negative feedback regulators defines growth factor signaling.
Ido Amit,Ami Citri,Ami Citri,Tal Shay,Yiling Lu,Menachem Katz,Fan Zhang,Gabi Tarcic,Doris R. Siwak,John P. Lahad,Jasmine Jacob-Hirsch,Ninette Amariglio,Nora Vaisman,Eran Segal,Gideon Rechavi,Uri Alon,Gordon B. Mills,Eytan Domany,Yosef Yarden +18 more
TL;DR: This study addresses the dynamics of growth factor signaling through profiling of protein phosphorylation and gene expression, demonstrating the presence of a kinetically defined cluster of delayed early genes that function to attenuate the early events ofgrowth factor signaling.
Journal ArticleDOI
Regulation of MAPKs by growth factors and receptor tyrosine kinases
TL;DR: Two cellular outcomes of growth factor action, namely proliferation and migration, are critically regulated by MAPKs and the underlying molecular mechanisms are described and detailed.
Journal ArticleDOI
Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation.
Yaron Mosesson,Keren Shtiegman,Menachem Katz,Yaara Zwang,Gyorgi Vereb,János Szöllosi,Yosef Yarden +6 more
TL;DR: It is reported that in isolation c-Cbl mediates monoubiquitylation rather than polyubiquitin-dependent proteasomal degradation of EGFRs, which implies that receptor tyrosine kinases are desensitized through conjugation of multiple monouboubiquitins, which is distinct from polyubanquitin -dependent proteAsomal degradation.