G
Gin-Wen Chang
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 2
Citations - 5871
Gin-Wen Chang is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Hypoxia-inducible factors & Von Hippel–Lindau tumor suppressor. The author has an hindex of 2, co-authored 2 publications receiving 5565 citations.
Papers
More filters
Journal ArticleDOI
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell,Michael S. Wiesener,Gin-Wen Chang,Steven C. Clifford,Emma C. Vaux,Matthew Edward Cockman,Charles C. Wykoff,Christopher W. Pugh,Eamonn R. Maher,Peter J. Ratcliffe,Peter J. Ratcliffe +10 more
TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.
Journal ArticleDOI
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
Matthew Edward Cockman,Norma Masson,David R. Mole,Panu Jaakkola,Gin-Wen Chang,Steven C. Clifford,Eamonn R. Maher,Christopher W. Pugh,Peter J. Ratcliffe,Patrick H. Maxwell +9 more
TL;DR: It is shown that extracts from VHL-deficient renal carcinoma cells have a defect in HIF-α ubiquitylation activity which is complemented by exogenous pVHL, and this defect was specific for Hif-α among a range of substrates tested.