M
Matthew Edward Cockman
Researcher at John Radcliffe Hospital
Publications - 7
Citations - 5886
Matthew Edward Cockman is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Hypoxia-inducible factors & Von Hippel–Lindau tumor suppressor. The author has an hindex of 3, co-authored 7 publications receiving 5580 citations. Previous affiliations of Matthew Edward Cockman include Wellcome Trust Centre for Human Genetics.
Papers
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Journal ArticleDOI
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
Patrick H. Maxwell,Michael S. Wiesener,Gin-Wen Chang,Steven C. Clifford,Emma C. Vaux,Matthew Edward Cockman,Charles C. Wykoff,Christopher W. Pugh,Eamonn R. Maher,Peter J. Ratcliffe,Peter J. Ratcliffe +10 more
TL;DR: It is indicated that the interaction between HIF-1 and pVHL is iron dependent, and that it is necessary for the oxygen-dependent degradation of HIF α-subunits, which may underlie the angiogenic phenotype of VHL-associated tumours.
Journal ArticleDOI
Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.
Matthew Edward Cockman,Norma Masson,David R. Mole,Panu Jaakkola,Gin-Wen Chang,Steven C. Clifford,Eamonn R. Maher,Christopher W. Pugh,Peter J. Ratcliffe,Patrick H. Maxwell +9 more
TL;DR: It is shown that extracts from VHL-deficient renal carcinoma cells have a defect in HIF-α ubiquitylation activity which is complemented by exogenous pVHL, and this defect was specific for Hif-α among a range of substrates tested.
Journal Article
Regulation of gene expression by oxygen levels in mammalian cells.
Christopher W. Pugh,G. W. Chang,Matthew Edward Cockman,A. C. R. Epstein,Jonathan M. Gleadle,Patrick H. Maxwell,L. G. Nicholls,J F O'Rourke,Peter J. Ratcliffe,E. C. Raybould,Ya-Min Tian,M. S. Wiesener,M. Wood,Charles C. Wykoff,K. M. Yeates +14 more
Patent
Assay for histidinyl hydroxylase activity
Christopher Joseph Schofield,Wei Ge,Matthew Edward Cockman,Peter John Ratcliffe,Mathew L. Coleman +4 more
TL;DR: In this paper, the authors proposed a method for detecting histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively.
Patent
Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxigenase and methods of using the same
Christopher J. Schofield,Kirsty Sarah Hewitson,Michael A. McDonough,Peter John Ratcliffe,Norma Masson,Matthew Edward Cockman +5 more
TL;DR: In this paper, a method of identifying an agent which modulates 2-oxoglutarate dependent oxygenase activity was proposed, which is the method comprising contacting a 2-OGD-dependent oxygenase and a test agent in the presence of a substrate comprising one or more ankyrin repeat, or fragment thereof.