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Panu Jaakkola

Researcher at Turku University Hospital

Publications -  64
Citations -  15997

Panu Jaakkola is an academic researcher from Turku University Hospital. The author has contributed to research in topics: Hypoxia (medical) & Cell. The author has an hindex of 28, co-authored 61 publications receiving 14261 citations. Previous affiliations of Panu Jaakkola include Åbo Akademi University & University of Helsinki.

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Journal ArticleDOI

Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation

Panu Jaakkola, +12 more
- 20 Apr 2001 - 
TL;DR: It is shown that the interaction between human pVHL and a specific domain of the HIF-1α subunit is regulated through hydroxylation of a proline residue by an enzyme the authors have termed Hif-α prolyl-hydroxylase (HIF-PH).
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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

Andrew C. R Epstein, +19 more
- 05 Oct 2001 - 
TL;DR: Direct modulation of recombinant enzyme activity by graded hypoxia, iron chelation, and cobaltous ions mirrors the characteristics of HIF induction in vivo, fulfilling requirements for these enzymes being oxygen sensors that regulate HIF.
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Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein.

Matthew Edward Cockman, +9 more
- 18 Aug 2000 - 
TL;DR: It is shown that extracts from VHL-deficient renal carcinoma cells have a defect in HIF-α ubiquitylation activity which is complemented by exogenous pVHL, and this defect was specific for Hif-α among a range of substrates tested.
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Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

Jan H. Marxsen, +8 more
- 01 Aug 2004 - 
TL;DR: A direct, negative regulatory mechanism is proposed, which limits accumulation of HIF-1alpha in Hypoxia and leads to accelerated degradation on reoxygenation after long-term hypoxia, which demonstrates functional relevance of the present results.