Gina Racine

TL;DR: Wang et al. as discussed by the authors found a strong positive correlation between plasma levels of soluble FasL (sFasL) and T cell surface expression of Fas/CD95 with the propensity of T cells to die and CD4 T cell counts.

TL;DR: Highly basic proteins were enriched by FFE fractionation, allowing many to be identified and characterized for the first time by proteomics analysis and evidence was obtained suggesting that some of these processes may be stage-specific.

TL;DR: The exoproteome obtained from in vitro promastigote cultures provides new perspectives on Leishmania biology with the possibility of vesicles playing a major role in protein turnover and also in cell death.

TL;DR: There is a significant decrease in splenic Tfh cells in SIVmac251-infected rhesus macaques (RMs) during the acute phase of infection, which persists thereafter, and a drastic remodeling of the lymphoid architecture of the spleen and LNs, which disrupts the crucial cell-cell interactions necessary to maintain memory B cells and T fh cells.

TL;DR: This study is the first analysis of the Leishmania mitochondrial proteome and offers powerful insights into the adaptations to this organelle during SbIII and MIL drug resistance.