Jean-Yves Lefrant

TL;DR: In patients with severe ARDS, early administration of a neuromuscular blocking agent improved the adjusted 90-day survival and increased the time off the ventilator without increasing muscle weakness.

TL;DR: A strategy for setting PEEP aimed at increasing alveolar recruitment while limiting hyperinflation did not significantly reduce mortality, but it did improve lung function and reduced the duration of mechanical ventilation and theduration of organ failure.

TL;DR: The use of a lung-protective ventilation strategy in intermediate-risk and high-risk patients undergoing major abdominal surgery was associated with improved clinical outcomes and reduced health care utilization.

TL;DR: Femoral venousCatheterization is associated with a greater risk of infectious and thrombotic complications than subclavian catheterization in ICU patients, and antibiotic administration via the catheter decreasedrisk of infectious complications.

TL;DR: ETI in ICU patients is associated with a high rate of immediate and severe life-threatening complications, and ETI performed by a junior physician supervised by a senior (i.e., two operators) was identified as a protective factor for the occurrence of complications.