N
Nuno Santarém
Researcher at University of Porto
Publications - 65
Citations - 4982
Nuno Santarém is an academic researcher from University of Porto. The author has contributed to research in topics: Leishmania infantum & Trypanosoma brucei. The author has an hindex of 19, co-authored 52 publications receiving 3638 citations. Previous affiliations of Nuno Santarém include Instituto de Biologia Molecular e Celular & Institute of Business & Medical Careers.
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Journal ArticleDOI
Immune response by nasal delivery of hepatitis B surface antigen and codelivery of a CpG ODN in alginate coated chitosan nanoparticles.
Olga Borges,Anabela Cordeiro-da-Silva,Joana Tavares,Nuno Santarém,Adriano de Sousa,Gerrit Borchard,H. E. Junginger +6 more
TL;DR: In this article, a new delivery system was loaded with the recombinant hepatitis B surface antigen (HBsAg) and applied to mice by the intranasal route, which gave rise to the humoral mucosal immune response.
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SIR2-deficient Leishmania infantum induces a defined IFN-gamma/IL-10 pattern that correlates with protection.
Ricardo Silvestre,Anabela Cordeiro-da-Silva,Anabela Cordeiro-da-Silva,Nuno Santarém,Nuno Santarém,Baptiste Vergnes,Denis Sereno,Ali Ouaissi,Ali Ouaissi,Ali Ouaissi +9 more
TL;DR: It is proposed that the polarization to a high IFN-γ/low IL-10 ratio after challenge is a clear indicator of vaccine success and these mutants, which presented attenuated virulence, represent a good model to understand the correlatives of protection in visceral leishmaniasis.
Journal ArticleDOI
Deception and manipulation: the arms of leishmania, a successful parasite
Pedro Cecílio,Begoña Pérez-Cabezas,Nuno Santarém,Joana Maciel,Vasco Rodrigues,Anabela Cordeiro da Silva +5 more
TL;DR: Here, it is revised how the parasite manipulates cell death and immune responses to survive and thrive in the shadow of the immune system.
Journal ArticleDOI
Impact of continuous axenic cultivation in Leishmania infantum virulence.
Diana Moreira,Nuno Santarém,Inês Loureiro,Joana Tavares,Joana Tavares,Ana Marta Silva,Ana Marina Amorim,Ali Ouaissi,Ali Ouaissi,Anabela Cordeiro-da-Silva,Anabela Cordeiro-da-Silva,Ricardo Silvestre +11 more
TL;DR: The data demonstrated that the use of parasites with distinct periods of axenic in vitro culture induce distinct infection rates and immunological responses and correlated this phenotype with a rapid loss of promastigote differentiation capacity.