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Giovanny J. Martínez-Colón
Researcher at University of Michigan
Publications - 10
Citations - 1788
Giovanny J. Martínez-Colón is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 7 publications receiving 1302 citations.
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Journal ArticleDOI
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
Raúl Muñoz-Planillo,Peter Kuffa,Giovanny J. Martínez-Colón,Brenna L. Smith,Thekkelnaycke M. Rajendiran,Gabriel Núñez +5 more
TL;DR: These results provide a unifying model for the activation of the NLRP3 inflammasome in which a drop in cytosolic K⁺ is the common step that is necessary and sufficient for caspase-1 activation.
Journal ArticleDOI
Prostaglandin E2 as a Regulator of Immunity to Pathogens.
TL;DR: This review describes one particular lipid regulator, prostaglandin E2 (PGE2), and describes its synthesis and signaling and what is known about the ability of this lipid to regulate immunity and host defense against viral, fungal and bacterial pathogens.
Journal ArticleDOI
Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2.
Racquel Domingo-Gonzalez,Giovanny J. Martínez-Colón,Alana J. Smith,Carolyne K. Smith,Megan N. Ballinger,Meng Xia,Susan Murray,Mariana J. Kaplan,Gregory A. Yanik,Bethany B. Moore +9 more
TL;DR: The results suggest blockade of the PGE2-EP2 or EP4 signaling pathway restores NETosis after transplantation, and provide the first description of a physiologic inhibitor of NETosis.
Journal ArticleDOI
IL-36γ is a crucial proximal component of protective type-1-mediated lung mucosal immunity in Gram-positive and -negative bacterial pneumonia.
Melissa A. Kovach,Benjamin H. Singer,Giovanny J. Martínez-Colón,Michael W. Newstead,Xianying Zeng,Peter Mancuso,Thomas A. Moore,Steven L. Kunkel,Marc Peters-Golden,Bethany B. Moore,Theodore J. Standiford +10 more
TL;DR: It is indicated that IL-36γ assumes a vital proximal role in the lung innate mucosal immunity during bacterial pneumonia by driving protective type-1 responses and classical macrophage activation.
Journal ArticleDOI
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
Giovanny J. Martínez-Colón,Kalani Ratnasiri,Heping Chen,Sizun Jiang,Elizabeth Zanley,Arjun Rustagi,Renu Verma,Han Chen,Jason R. Andrews,Kirsten D. Mertz,Alexandar Tzankov,Dan E. Azagury,Jack H. Boyd,Garry P. Nolan,Christian M. Schürch,Matthias S. Matter,Catherine A. Blish,Tracey McLaughlin +17 more
TL;DR: It is suggested that SARS-CoV-2 infection of adipose tissue could contribute to COVID-19 severity through replication of virus within adipocytes and through induction of local and systemic inflammation driven by infection of fat tissue-resident macrophages.