M
Matthias S. Matter
Researcher at University Hospital of Basel
Publications - 100
Citations - 3990
Matthias S. Matter is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 27, co-authored 79 publications receiving 2578 citations. Previous affiliations of Matthias S. Matter include University of Basel & University of Bern.
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Journal ArticleDOI
Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients
Luca Quagliata,Matthias S. Matter,Salvatore Piscuoglio,Salvatore Piscuoglio,Leila Arabi,Christian Ruiz,Alfredo Procino,Michal Kovac,Francesca Moretti,Zuzanna Makowska,Tujana Boldanova,Jesper B. Andersen,Monika Hämmerle,Luigi Tornillo,Markus H. Heim,Sven Diederichs,Clemente Cillo,Luigi Terracciano +17 more
TL;DR: It is demonstrated that the levels of HOTTIP and HOXA13 are associated with HCC patients' clinical progression and predict disease outcome, and novel insights on the function of lncRNA‐driven hepatocarcinogenesis are provided.
Journal ArticleDOI
Organoid Models of Human Liver Cancers Derived from Tumor Needle Biopsies
Sandro Nuciforo,Isabel Fofana,Matthias S. Matter,Tanja Blumer,Diego Calabrese,Tujana Boldanova,Salvatore Piscuoglio,Stefan Wieland,Femke Ringnalda,Gerald Schwank,Luigi Terracciano,Charlotte K.Y. Ng,Markus H. Heim +12 more
TL;DR: The generation of long-term organoid cultures from tumor needle biopsies of HCC patients with various etiologies and tumor stages is reported and it is shown that liver cancer organoids can be used to test sensitivity to sorafenib.
Journal ArticleDOI
Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends
TL;DR: A second generation of mTOR pathway inhibitors has been developed recently and is being tested in various clinical trials of solid cancers, and has been used in preclinical HCC models.
Journal ArticleDOI
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer
Mohsen Malehmir,Dominik Pfister,Suchira Gallage,Marta Szydlowska,Donato Inverso,Donato Inverso,Elena Kotsiliti,Elena Kotsiliti,Valentina Leone,Moritz Peiseler,Bas G.J. Surewaard,Dominik Rath,Adnan Ali,Monika Julia Wolf,Hannah K. Drescher,Marc E. Healy,Daniel Dauch,Daniela C. Kroy,Oliver Krenkel,Marlene Kohlhepp,Thomas Engleitner,Thomas Engleitner,Alexander Olkus,Alexander Olkus,Tjeerd P. Sijmonsma,Julia Volz,Carsten Deppermann,David Stegner,Patrick M. Helbling,César Nombela-Arrieta,Anahita Rafiei,Martina Hinterleitner,Marcel Rall,Florian Baku,Oliver Borst,Caroline L. Wilson,Jack Leslie,Tracy O'Connor,Christopher J. Weston,David H. Adams,Lozan Sheriff,Ana Teijeiro,Marco Prinz,Ruzhica Bogeska,Natasha S Anstee,Malte N. Bongers,Mike Notohamiprodjo,Tobias Geisler,Dominic J. Withers,Jerry Ware,Derek A. Mann,Hellmut G. Augustin,Hellmut G. Augustin,Alexandros Vegiopoulos,Michael D. Milsom,Adam J. Rose,Patricia F. Lalor,Josep M. Llovet,Josep M. Llovet,Josep M. Llovet,Roser Pinyol,Frank Tacke,Roland Rad,Roland Rad,Matthias S. Matter,Nabil Djouder,Paul Kubes,Percy A. Knolle,Kristian Unger,Lars Zender,Lars Zender,Bernhard Nieswandt,Meinrad Gawaz,Achim Weber,Mathias Heikenwalder,Mathias Heikenwalder +75 more
TL;DR: It is shown that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance, offering a potential approach to treat non-alcoholic steatohepatitis and prevent subsequent progression to hepatocellular carcinoma.
Journal ArticleDOI
SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment
Chien-Ting Wu,Peter V. Lidsky,Yinghong Xiao,Ivan T. Lee,Ran Cheng,Tsuguhisa Nakayama,Sizun Jiang,Janos Demeter,Romina J. Bevacqua,Charles A. Chang,Robert L. Whitener,Anna K. Stalder,Bokai Zhu,Han Chen,Yury Goltsev,Alexandar Tzankov,Jayakar V. Nayak,Garry P. Nolan,Matthias S. Matter,Raul Andino,Peter K. Jackson +20 more
TL;DR: In this paper, the SARS-CoV-2 infection attenuates pancreatic insulin levels and secretion and induces β cell apoptosis, each rescued by NRP1 inhibition.