G
Gisela Lättig-Tünnemann
Researcher at Charité
Publications - 11
Citations - 687
Gisela Lättig-Tünnemann is an academic researcher from Charité. The author has contributed to research in topics: Arc (protein) & Neuroprotection. The author has an hindex of 9, co-authored 11 publications receiving 566 citations. Previous affiliations of Gisela Lättig-Tünnemann include Humboldt University of Berlin & Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.
Gisela Lättig-Tünnemann,Manuel Prinz,Daniel Hoffmann,Joachim Behlke,Caroline Palm-Apergi,Ingo Morano,Henry D. Herce,M. Cristina Cardoso,M. Cristina Cardoso +8 more
TL;DR: It is demonstrated that the transduction efficiency of arginine-rich peptides increases with higher peptide structural rigidity, and it is proposed that guanidinium groups are forced into maximally distant positions by cyclization, leading to enhanced cell penetration.
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SUMO2/3 Conjugation is an Endogenous Neuroprotective Mechanism:
Anna Lena Datwyler,Gisela Lättig-Tünnemann,Wei Yang,Wulf Paschen,Wulf Paschen,Sabrina Lin Lin Lee,Ulrich Dirnagl,Matthias Endres,Christoph Harms +8 more
TL;DR: Viability was unaffected by SUMO2/3 silencing unless neurons were stressed by transient oxygen–glucose deprivation (OGD), which suggests that activation of SUMO 2/3 conjugation is an endogenous neuroprotective stress response.
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Principles of protein targeting to the nucleolus
Robert M. Martin,Gohar Ter-Avetisyan,Henry D. Herce,Anne K. Ludwig,Gisela Lättig-Tünnemann,M. Cristina Cardoso +5 more
TL;DR: It is found that the nucleolar compartment is particularly acidic when compared to the surrounding nucleoplasm and, hence, provides the ideal electrochemical environment to bind poly-arginine containing proteins and the same principles apply to cells from insects to man, indicating that this mechanism is highly conserved throughout evolution.
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Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.
Christian J. Hoffmann,Ulrike Harms,André Rex,Frank Szulzewsky,Susanne A. Wolf,Ulrike Grittner,Gisela Lättig-Tünnemann,Michael Sendtner,Helmut Kettenmann,Ulrich Dirnagl,Matthias Endres,Christoph Harms +11 more
TL;DR: Endothelial Stat3 regulatesAngiogenesis, axon growth, and extracellular matrix remodeling and is essential for long-term recovery after stroke and might serve as a potent target for stroke treatment after the acute phase by fostering angiogenesis and neuroregeneration.
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TAT-apoptosis repressor with caspase recruitment domain protein transduction rescues mice from fulminant liver failure†
Junfeng An,Christoph Harms,Gisela Lättig-Tünnemann,Gernot Sellge,Ana D. Mandić,Y Malato,Arnd Heuser,Matthias Endres,Christian Trautwein,Stefan Donath,Stefan Donath +10 more
TL;DR: This work suggests that TAT‐ARC confers hepatoprotection upstream and at the hepatocyte level, and identified JNK as a novel target of ARC.