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Ingo Morano
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 146
Citations - 5969
Ingo Morano is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Myosin & Myosin light-chain kinase. The author has an hindex of 42, co-authored 146 publications receiving 5695 citations. Previous affiliations of Ingo Morano include Charité & University of Cologne.
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Backbone rigidity and static presentation of guanidinium groups increases cellular uptake of arginine-rich cell-penetrating peptides.
Gisela Lättig-Tünnemann,Manuel Prinz,Daniel Hoffmann,Joachim Behlke,Caroline Palm-Apergi,Ingo Morano,Henry D. Herce,M. Cristina Cardoso,M. Cristina Cardoso +8 more
TL;DR: It is demonstrated that the transduction efficiency of arginine-rich peptides increases with higher peptide structural rigidity, and it is proposed that guanidinium groups are forced into maximally distant positions by cyclization, leading to enhanced cell penetration.
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From totipotent embryonic stem cells to spontaneously contracting smooth muscle cells: a retinoic acid and db-cAMP in vitro differentiation model.
Marek Drab,Hermann Haller,Rostislav Bychkov,Bettina Erdmann,Carsten Lindschau,Hannelore Haase,Ingo Morano,Friedrich C. Luft,Anna M. Wobus +8 more
TL;DR: A retinoic acid + db‐cAMP‐inducible embryonic stem cell model of in vitro vasculogenesis and ES cell‐derived cells expressing VSMC‐specific MHC and functional VSMC properties may be a suitable system to study mechanisms of VSMC differentiation.
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The failing human heart is unable to use the Frank-Starling mechanism.
Robert H. G. Schwinger,Michael Böhm,Andrea Koch,Ulrich Schmidt,Ingo Morano,H.-J. Eissner,P. Überfuhr,B Reichart,Erland Erdmann +8 more
TL;DR: Evidence is provided for an impaired force-tension relation in failing human myocardium that might be explained by a failure of the myofibrils to increase the Ca2+ sensitivity after an increase of the sarcomere length.
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Counting target molecules by exponential polymerase chain reaction: Copy number of mitochondrial DNA in rat tissues
TL;DR: The actual number of target molecules of the polymerase chain reaction can be determined by measuring the concentration of product accumulating in consecutive cycles, and mitochondria were found to contain 1 to 3 DNA molecules.
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Tuning the human heart molecular motors by myosin light chains
TL;DR: The various subunits of human heart myosin in health and disease are described and their functions are discussed.