J
Jia Yu
Researcher at National University of Singapore
Publications - 13
Citations - 684
Jia Yu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Wnt signaling pathway & PORCN. The author has an hindex of 9, co-authored 13 publications receiving 528 citations.
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Journal ArticleDOI
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
Gary S. Coombs,Jia Yu,Claire A. Canning,Charles A. Veltri,Tracy M. Covey,Jit Kong Cheong,Velani Utomo,Nikhil Banerjee,Zong Hong Zhang,Raquel C. Jadulco,Gisela P. Concepcion,Tim S. Bugni,Mary Kay Harper,Ivana Mihalek,C. Michael Jones,Chris M. Ireland,David M. Virshup +16 more
TL;DR: It is proposed that WLS binds Wnts in part through a lipid-binding domain, and that vacuolar acidification is required to release palmitoylated WNT3A from WLS in secretory vesicles, possibly to facilitate transfer of Wnt3A to a soluble carrier protein.
Journal ArticleDOI
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities
Rani Najdi,Kyle D. Proffitt,Stephanie Sprowl,Simran Kaur,Jia Yu,Tracy M. Covey,David M. Virshup,Marian L. Waterman +7 more
TL;DR: It is found that the core Wnt modification and secretion proteins Porcupine (PORCN) and Wntless (WLS) are essential for all Wnts to signal through β-catenin-dependent and independent pathways.
Journal ArticleDOI
WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.
TL;DR: It is found that endogenous WLS binds Wnts in the endoplasmic reticulum (ER), cycles to the PM, and then returns to the ER through the Golgi, an integral part of the WLS transport cycle.
Journal ArticleDOI
Updating the Wnt pathways
Jia Yu,David M. Virshup +1 more
TL;DR: New findings regarding the dedicated Wnt production and secretion pathway with potential therapeutic targets that might be beneficial for patients with Wnt-related diseases are focused on.
Journal ArticleDOI
Wnts and the hallmarks of cancer.
TL;DR: Wnt signaling pathway and its involvement in cancers have been extensively investigated and widespread roles of Wnt signaling in human cancers highlight the importance and feasibility of targeting this signaling pathway for cancer treatment.