Giulia Menozzi

TL;DR: The new 4-aminopyrazolo[3,4-d]pyrimidines bearing various substituents at the position 1 and 6, showed antiproliferative activity toward A431 cells, were found to be inhibitors of Src phosphorylation, and induced apoptotic cell death.

TL;DR: In this article, open-chain and cyclic sym-1,3-diones with N,N-dimethylformamide dimethyl acetal gave, generally in high yield, a series of sym-2-dimethylaminomethylene-1.3-Diones which reacted with phenylhydrazine and methylhydrazines to afford, generally, in satisfactory yield, 1,5-disubstituted 4-acylpyrazoles.

TL;DR: In this article, a series of carbinols 3a-f was prepared starting from methanols 1a -f via oxidation with pyridinium chlorochromate to aldehydes 2a-F, followed by a Grignard reaction of the latter.

TL;DR: The synthesis of new pyrazolo[3,4-d]pyrimidine derivatives along with their biological properties as inhibitors of isolated Src and cell line proliferation are reported, finding several of them to be more active than the reference compound.

TL;DR: The microbiological evaluation carried out on newly synthesized compounds included in vitro assays for antifungal, antibacterial and antimycobacterial activities was superior to that of clotrimazole and econazole, which were used as reference drugs.