Giuliano Pillolla

TL;DR: The results indicate that the two pathways work in a cooperative manner to release endocannabinoids in the VTA, where they play a role as retrograde messengers for DSE via CB1-Rs.

TL;DR: This work shows that physiologically relevant patterns of synaptic activity induce a transient suppression of excitatory transmission onto dopamine neurons in vitro, and indicates that dopamine neurons release 2-AG to shape afferent activity and ultimately their own firing pattern.

TL;DR: It is suggested that an enduring form of neuronal adaptation occurs in DA neurons after subchronic cannabinoid intake at a young age, affecting subsequent responses to drugs of abuse.

TL;DR: Results provide further support for the existence of a neural circuit in which dopamine and oxytocin influence both the consummatory and motivational/rewarding aspects of sexual behaviour.

TL;DR: Analysis of modulation of nicotine effects by the endocannabinoid system on dopamine neurons in the ventral tegmental area indicates for the first time that the anorexic lipids OEA and PEA possess neuromodulatory properties as endogenous ligands of PPAR-α in the brain and provide a potential new target for the treatment of nicotine addiction.