Giuseppe Mancuso

TL;DR: Multigenome analysis and screening described here represent a powerful strategy for identifying potential vaccine candidates against highly variable pathogens.

TL;DR: This work shows that phagosomal bacteria such as group B streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required Toll-like receptor 7, the adaptor MyD88 and the transcription factor IRF1, all of which localized together with bacterial products in degradative vacuoles bearing lysosomal markers.

TL;DR: It is shown in this study that IFN-αβ signaling is crucial for host defenses against different bacteria, including group B streptococci (GBS), pneumococci, and Escherichia coli, and Animals lacking bothIFN- αβR and IFn-γR displayed additive lethality, suggesting that the two IFN types have complementary and nonredundant roles in host defenses.

TL;DR: In this paper, both the mode of action and the mechanisms of resistance of commonly used antimicrobials are examined and the current state of AMR in the most critical resistant bacteria as determined by the WHO's global priority pathogens list.

TL;DR: It is shown that murine bone marrow-derived conventional dendritic cells responded to GBS by secreting IL-1β and IL-18, and that mice lacking NLRP3, apoptosis-associated speck-like protein, or caspase-1 were considerably more susceptible to infection than wild-type mice.