P
Philipp Henneke
Researcher at University of Freiburg
Publications - 101
Citations - 4411
Philipp Henneke is an academic researcher from University of Freiburg. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 25, co-authored 90 publications receiving 3534 citations. Previous affiliations of Philipp Henneke include University Medical Center Freiburg.
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Journal ArticleDOI
IgG4-related disease.
Journal ArticleDOI
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection.
Richard Malley,Philipp Henneke,Sarah C. Morse,Michael J. Cieslewicz,Marc Lipsitch,Claudette M. Thompson,Evelyn A. Kurt-Jones,James C. Paton,Michael R. Wessels,Douglas T. Golenbock +9 more
TL;DR: The interaction of pneumolysin with TLR4 is critically involved in the innate immune response to pneumococcus and is found to stimulate tumor necrosis factor-α and IL-6 release in wild-type macrophages but not in macrophage from mice with a targeted deletion of the cytoplasmic TLR-adapter molecule myeloid differentiation factor 88, suggesting the involvement of the TLRs in pneumoly sin recognition.
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Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.
A. Sassi,Sandra Lazaroski,Gang Wu,Stuart M. Haslam,Manfred Fliegauf,Fethi Mellouli,Turkan Patiroglu,Ekrem Unal,Mehmet Akif Ozdemir,Zineb Jouhadi,Khadija Khadir,Leila Ben-Khemis,Meriem Ben-Ali,Imen Ben-Mustapha,Lamia Borchani,Dietmar Pfeifer,Thilo Jakob,Monia Khemiri,A. Charlotta Asplund,Manuela O. Gustafsson,Karin E. Lundin,Elin Falk-Sörqvist,Lotte Moens,Hatice Eke Gungor,Karin R. Engelhardt,Magdalena Dziadzio,Hans J. Stauss,Bernhard Fleckenstein,Rebecca Meier,Khairunnadiya Prayitno,Andrea Maul-Pavicic,Sandra Schaffer,Mirzokhid Rakhmanov,Philipp Henneke,Helene Kraus,Hermann Eibel,Uwe Kölsch,Sellama Nadifi,Mats Nilsson,Mohamed Bejaoui,Alejandro A. Schäffer,C. I. Edvard Smith,Anne Dell,Mohamed-Ridha Barbouche,Bodo Grimbacher,Bodo Grimbacher +45 more
TL;DR: In this paper, a linkage analysis of candidate genes in an 11.9-Mb linkage region on chromosome 6 shared by two multiplex families identified two homozygous mutations in PGM3 that segregated with disease status and followed recessive inheritance.
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Activation of the NLRP3 Inflammasome by Group B Streptococci
Alessandro Costa,Rahul Gupta,Giacomo Signorino,Antonio Malara,Francesco Cardile,Carmelo Biondo,Angelina Midiri,Roberta Galbo,Patrick Trieu-Cuot,Salvatore Papasergi,Giuseppe Teti,Philipp Henneke,Giuseppe Mancuso,Douglas T. Golenbock,Concetta Beninati +14 more
TL;DR: It is shown that murine bone marrow-derived conventional dendritic cells responded to GBS by secreting IL-1β and IL-18, and that mice lacking NLRP3, apoptosis-associated speck-like protein, or caspase-1 were considerably more susceptible to infection than wild-type mice.
Journal ArticleDOI
Lipoproteins Are Critical TLR2 Activating Toxins in Group B Streptococcal Sepsis
Philipp Henneke,Shaynoor Dramsi,Giuseppe Mancuso,Kamila Chraibi,Kamila Chraibi,Elisabeth Pellegrini,Christian Theilacker,Johannes Hübner,Sandra Santos-Sierra,Giuseppe Teti,Douglas T. Golenbock,Claire Poyart,Patrick Trieu-Cuot +12 more
TL;DR: In this article, the role of GBS lipoproteins in this process was examined by inactivating two genes essential for bacterial lipoprotein (BLP) maturation: the prolipoprotein diacylglyceryl transferase gene (lgt) and the lipiprotein signal peptidase gene(lsp).