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Giuseppe Paglietti
Researcher at University of Sassari
Publications - 125
Citations - 2198
Giuseppe Paglietti is an academic researcher from University of Sassari. The author has contributed to research in topics: Quinoxaline & Ring (chemistry). The author has an hindex of 24, co-authored 125 publications receiving 2016 citations.
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Journal ArticleDOI
Synthesis and Anti-Picornaviridae In Vitro Activity of a New Class of Helicase Inhibitors the N,N-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides
Antonio Carta,Mario Loriga,S. Piras,Giuseppe Paglietti,Marco Ferrone,Maurizio Fermeglia,Sabrina Pricl,P. La Colla,Gabriella Collu,Tiziana Sanna,R. Loddo +10 more
TL;DR: Molecular modeling investigations showed that active compounds may interact with the binding site of the Sb-1 helicase and that their free binding energy values are in agreement with their EC(50)s values.
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Quinoxaline chemistry: Part 11: 3-Phenyl-2 [phenoxy- and phenoxymethyl]-6(7) or 6,8-substituted quinoxalines and N -[4-(6(7)-substituted or 6,8-disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl]benzoylglutamates: synthesis and evaluation of in vitro anticancer activity and enzymatic inhibitory activity against dihydrofolate reductase and thymidylate synthase
TL;DR: Inhibitory activity against dihydrofolate reductase (DHFR) (bovine and rat liver) was determined for the most active compounds and showed that this type of quinoxaline exhibited an appreciable activity in comparison with the previously described aza analogues.
Journal Article
1,2,3-triazolo[4,5-h]quinolines. III. Preparation and antimicrobial evaluation of 4-ethyl-4,7-dihydro-1(2)-R-1(2)H triazolo[4,5-h]quinolin-7-one-6-carboxylic acids as anti-infectives of the urinary tract.
TL;DR: The biological results indicate that the type of annelation of triazolo[4,5-f]quinoline carboxylic acids is not profitable for antimicrobial activity.
Journal Article
Quinoxaline chemistry. Part 5. 2-(R)-benzylaminoquinoxalines as nonclassical antifolate agents. Synthesis and evaluation of in vitro anticancer activity.
TL;DR: Preliminary screening performed at NCI on twenty-two compounds showed that most derivatives exhibited a moderate to strong growth inhibition activity on various tumor panel cell lines between 10(-5) and 10(-4) molar concentrations.
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5-Acetyl-2-arylbenzimidazoles as antiviral agents. Part 4
Gabriella Vitale,Paola Corona,Mario Loriga,Antonio Carta,Giuseppe Paglietti,Gabriele Giliberti,Giuseppina Sanna,Pamela Farci,Maria Elena Marongiu,Paolo La Colla +9 more
TL;DR: New variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the three genera of the Flaviviridae family, i.e. Pestivirus, Flavivirus and Hepacivirus.