Giuseppe Realdi

TL;DR: In HB s Ag-positive chronic active hepatitis presence of HB e Ag in serum identifies an early, although prolonged, phase of active virus replication that is frequently followed by the disappearance of complete virus particles from serum and appearance of anti-HB e .

TL;DR: HDV infection increases the risk for HCC threefold and for mortality twofold in patients with cirrhosis type B.

TL;DR: Findings indicate that patients with severe chronic active hepatitis and persistent hepatitis B virus replication are at very high risk of rapid progression to cirrhosis.

TL;DR: Findings indicate that, in chronic hepatitis type B, termination of virus replication is associated in most patients with biochemical and histologic regression of inflammatory activity, and after anti‐HBe seroconversion has occurred, virus replication and liver disease may persist or reactivate in a small proportion of patients thus giving origin to the well‐recognized group of anti-HBe positive, hepatitis B virus DNA‐positive chronic hepatitistype B.

TL;DR: In conclusion, metronidazole or clarithromycin pretreatment resistant H. pylori are the main factors responsible for treatment failure with regimens using these compounds.