Showing papers in "Hepatology in 1986"

TL;DR: It is concluded that chemical measurement of hepatic iron concentration, when corrected for the age of the subject, reliably distinguishes early hemochromatosis from alcoholic siderosis, and that there appears to be a threshold level of Hepatic iron above which there is a high risk of fibrosis.

TL;DR: Variant isoenzymes produced at the two polymorphic alcohol dehydrogenase loci account for the differences in enzyme electrophoretic patterns observed among individuals, and this may accounts for the 2‐ to 3‐fold variation in alcohol elimination rate among individuals.

TL;DR: In patients with fulminant hepatitis B, the absence of HBsAg in serum as detected by radioimmunoassay has an independent, favorable prognostic value and is significantly higher than the survival rate observed in the 94 HBs Ag‐positive patients.

TL;DR: In normal rat liver, Kupffer cells were unequivocally identified using peroxidase cytochemistry by light microscopy in semithin plastic sections and showed a lower activity of latex uptake, even at overloading doses.

TL;DR: Comparison of “responders” and “nonresponder” showed no significant differences in baseline laboratory and hemodynamic parameters, in the severity of the liver disease, and in theheart rate and blood pressure response to propranolol, nor in the proPranolol plasma levels achieved 2 hr after proPRanolol administration.

TL;DR: Findings indicate that, in chronic hepatitis type B, termination of virus replication is associated in most patients with biochemical and histologic regression of inflammatory activity, and after anti‐HBe seroconversion has occurred, virus replication and liver disease may persist or reactivate in a small proportion of patients thus giving origin to the well‐recognized group of anti-HBe positive, hepatitis B virus DNA‐positive chronic hepatitistype B.

TL;DR: This model, which represents the first rat model to achieve such advanced experimental alcohol‐ induced liver injury, possesses the obvious potential for further use in studies of ethanol‐nutrient interactions in the pathogenesis of alcohol‐induced liver injury.

TL;DR: Patients' neutrophils from patients with cirrhosis are unable to detoxify hydrogen peroxide effectively and that this is a result of reduced levels of glutathione in the cells, and the consequent increase in oxidant stress, both intra‐and extracellularly, may be the cause of phagocytic and degranulation defects.

TL;DR: Three collagen types (I, III and IV) and fibronectin were localized in normal and alcoholic human liver by light and electron microscopy using the indirect immunoperoxidase technique and hepatocytes were found to contain little type I collagen and large amount of fibronECTin.

TL;DR: It is concluded that the finding of an antimitochondrial antibody titer ≥1/40 is strongly suggestive of primary biliary cirrhosis even in the absence of symptoms and the presence of a normal alkaline phosphatase.

TL;DR: The addition of nitroglycerin to a vasopressin infusion results in a lower rate of complications and is more effective in controlling variceal hemorrhage.

TL;DR: Hepatic transplantation, successfully performed in one patient, would appear to offer the best chance of survival for the majority of these patients and the patients given corticosteroids did not have a statistically significant improvement in survival.

TL;DR: The two cirrhotic groups did not differ significantly from each other in coagulation or in fibrinolytic parameters, although liver function was more impaired in nonalcoholic cirrhosis, and the free fast‐acting plasminogen activator inhibitor showed extremely high and extremely low levels in some patients among all three groups.

TL;DR: Analysis of clinical and laboratory data and the subsequent clinical course of 93 consecutive adult patients who underwent orthotopic liver transplantation for various chronic advanced liver diseases concluded that the strongest risk factor for early major bacterial infection was the serum creatinine level, which achieved an accuracy of 69% for a creat inine level greater than 1.58 mg per dl.

TL;DR: The results demonstrate that: (i) the Kupffer cells are not the only cells of the hepatic sinusoid capable of phagocytosis; and (ii) under conditions where the phagocytes are impaired, the endothelial cells may participate in the clearance of large particles from the blood.

TL;DR: In a chimpanzee model of acute type B hepatitis, at the time of onset of hepatitis B virus replication and before the development of immunity to hepatitis Birus, interferon is present in the plasma and there is an increase in the display of HLA class I, but not class II proteins, on the hepatocyte membrane.

TL;DR: It is concluded that propranolol is not effective for the prevention of variceal rebleeding, when administered early following the initial bleed, in cirrhotics unselected with respect to the severity of the liver disease.

TL;DR: It is suggested that hyaluronate levels reflect both active fibrosis and hepatic failure and may be a quantitative marker of severity of hepatic injury.

TL;DR: This study shows that the addition of sublingual nitroglycerin to intravenous vasopressin does not alter the efficacy of vasoppressin alone in controlling hemorrhage from esophageal varices, but it does significantly reduce the complications.

TL;DR: Bacterial sepsis was the leading cause of death and accounted for 17 of the 21 deaths in which infection was present at the time of death, and the most frequently isolated bacteria were Pseudomonas and other enteric Gram‐negative bacilli.

TL;DR: In in vitro tests, it is reported that some hepatitis B virus carriers have a reduced capacity to produce α‐ and γ‐interferon which is unrelated to the level of viral replication and to the severity of the liver disease and that thelevel of 2–5 oligoadenylate synthetase in their livers is only minimally elevated compared to controls.

TL;DR: It is suggested that bile infection precedes rather than follows the formation of brown stones, and in patients having brown pigment bile stones, recurrent 18 and 36 months after cholecystectomy.

TL;DR: The effect of terlipressin (N‐α‐triglycyl‐8‐lysinevasopressin) in bleeding esophageal varices was evaluated in a prospective placebo‐controlled study.

TL;DR: Seventy‐two consecutively admitted patients with biopsy‐proven alcoholic cirrhosis and a bleeding episode endoscopically proven to originate from ruptured esophageal varices were studied.

TL;DR: Phosphate, known to inhibit binding to the active site lysine of RNase, prevented the inhibition of catalytic activity caused by adduct formation, indicating that the binding of acetaldehyde toLysine at the catalytic site can inhibit enzyme activity.

TL;DR: Measurements of variceal pressure with a noninvasive endoscopic pressure gauge and by directvariceal puncture were performed in 20 cirrhotic patients with portal hypertension in the course of the first session of therapeutic sclerotherapy following an episode of varicesal bleeding.

TL;DR: The data suggest that early CCl4 toxicity is adirect consequence of its solvent properties and is partially reversible; subsequent damage may be mediated by lipid peroxidation.