G
Godelieve R.F. Claes
Researcher at Maastricht University
Publications - 12
Citations - 295
Godelieve R.F. Claes is an academic researcher from Maastricht University. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 5, co-authored 8 publications receiving 166 citations. Previous affiliations of Godelieve R.F. Claes include Maastricht University Medical Centre.
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Journal ArticleDOI
A mutation update for the FLNC gene in myopathies and cardiomyopathies
Job A J Verdonschot,Els K. Vanhoutte,Godelieve R.F. Claes,Apollonia T. J. M. Helderman-van den Enden,Janneke G. J. Hoeijmakers,Debby M.E.I. Hellebrekers,Amber de Haan,Imke Christiaans,Ronald H. Lekanne Deprez,Hanne M Boen,Emeline M. Van Craenenbroeck,Bart Loeys,Yvonne M. Hoedemaekers,Carlo Marcelis,Marlies Kempers,Esther Brusse,Jaap I. van Waning,Jaap I. van Waning,Annette F. Baas,Dennis Dooijes,Folkert W. Asselbergs,Daniela Q.C.M. Barge-Schaapveld,Pieter Koopman,Arthur van den Wijngaard,Stephane Heymans,Stephane Heymans,Ingrid P.C. Krapels,Han G. Brunner,Han G. Brunner,Han G. Brunner +29 more
TL;DR: The clinical spectrum of FLNC suggests different pathomechanisms related to variant types and their location in the gene, which is crucial for structural integrity and cell signaling of the sarcomere.
Journal ArticleDOI
Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects.
Terry Vrijenhoek,Ken Kraaijeveld,Martin G Elferink,Joep de Ligt,Elcke J. Kranendonk,Gijs W. E. Santen,Isaac J. Nijman,Derek Butler,Godelieve R.F. Claes,Adalberto Costessi,Wim Dorlijn,Winfried Van Eyndhoven,Dicky J. J. Halley,Mirjam C G N van den Hout,Steven van Hove,Lennart Johansson,Jan D. H. Jongbloed,Rick Kamps,Christel E M Kockx,Bart de Koning,Marjolein Kriek,Ronald Lekanne Dit Deprez,Hans Lunstroo,Marcel M.A.M. Mannens,Olaf R.F. Mook,Marcel R. Nelen,Corrette Ploem,Marco Rijnen,Jasper J. Saris,Richard J. Sinke,Erik A. Sistermans,Marjon van Slegtenhorst,Frank Sleutels,Nienke van der Stoep,Marianne van Tienhoven,Martijn Vermaat,Maartje J Vogel,Quinten Waisfisz,Janneke Marjan Weiss,Arthur van den Wijngaard,Wilbert van Workum,Helger Ijntema,Bert van der Zwaag,Wilfred F. J. van IJcken,Johan T. den Dunnen,Joris A. Veltman,Raoul C.M. Hennekam,Edwin Cuppen +47 more
TL;DR: It is concluded that alternative diagnoses may infer a certain level of ‘greediness’ to come to a positive diagnosis in interpreting sequencing results, and invited clinical geneticists, physicians, researchers, bioinformatics experts and patients to reconsider their role and position in future diagnostic genome care.
Journal ArticleDOI
Hypertrophic remodelling in cardiac regulatory myosin light chain (MYL2) founder mutation carriers
Godelieve R.F. Claes,Florence H J van Tienen,Patrick J. Lindsey,Ingrid P.C. Krapels,Apollonia T. J. M. Helderman-van den Enden,Marije B. Hoos,Yvette E.G. Barrois,Johanna W.H. Janssen,Aimee D C Paulussen,Jan-Willem E M Sels,Simone H.H. Kuijpers,J. Peter van Tintelen,Maarten P. van den Berg,Wilfred F. Heesen,Pablo García-Pavía,Andreas Perrot,Imke Christiaans,Simone Salemink,Carlo Marcelis,Hubert J.M. Smeets,Han G. Brunner,Han G. Brunner,Paul G.A. Volders,Arthur van den Wijngaard +23 more
TL;DR: The findings suggest that the presence of hypertension or another risk factor for hypertrophy should not be an exclusion criterion for genetic studies, and early diagnosis of risk factors is important for early treatment of MYL2 mutation carriers.
Journal ArticleDOI
Implications of Genetic Testing in Dilated Cardiomyopathy.
Job Verdonschot,Mark R. Hazebroek,Ingrid P.C. Krapels,Michiel T H M Henkens,Anne Raafs,Ping Wang,Jort J. Merken,Godelieve R.F. Claes,Els K. Vanhoutte,Arthur van den Wijngaard,Stephane Heymans,Han G. Brunner +11 more
TL;DR: One in 5 patients with an established nongenetic risk factor or a nonfamilial disease still carries a pathogenic gene variant, characterized by a profile of electrical phenotypes, which carries increased risk for adverse outcomes.
Journal ArticleDOI
Next-generation sequencing-based genome diagnostics across clinical genetics centers: implementation choices and their effects (vol 23, pg 1142, 2015)
Terry Vrijenhoek,Ken Kraaijeveld,Martin G Elferink,Joep de Ligt,Elcke J. Kranendonk,Gijs W. E. Santen,Isaac J. Nijman,Derek Butler,Godelieve R.F. Claes,Adalberto Costessi,Wim Dorlijn,Winfried Van Eyndhoven,Dicky J. J. Halley,Mirjam C G N van den Hout,Steven van Hove,Lennart Johansson,Jan D. H. Jongbloed,Rick Kamps,Christel E M Kockx,Bart de Koning,Marjolein Kriek,Ronald Lekanne Dit Deprez,Hans Lunstroo,Marcel M.A.M. Mannens,Olaf R.F. Mook,Marcel R. Nelen,Corrette Ploem,Marco Rijnen,Jasper J. Saris,Richard J. Sinke,Erik A. Sistermans,Marjon van Slegtenhorst,Frank Sleutels,Nienke van der Stoep,Marianne van Tienhoven,Martijn Vermaat,Maartje J Vogel,Quinten Waisfisz,Janneke Marjan Weiss,Arthur van den Wijngaard,Wilbert van Workum,Helger Ijntema,Bert van der Zwaag,Wilfred F. J. van IJcken,Johan T. den Dunnen,Joris A. Veltman,Raoul C.M. Hennekam,Edwin Cuppen +47 more