Christel E M Kockx

TL;DR: Regulation of disease-associated genes by a Sox2-Chd7 complex provides a plausible explanation for several malformations associated with SOX2 anophthalmia syndrome or CHARGE syndrome.

TL;DR: In this paper, the dynamics of the composition of the Gata1 complex were studied, in particular, the binding of the negative regulators Eto2 and Mtgr1, in the context of their genome-wide targets.

TL;DR: Results reveal a regulatory paradigm that directs distinct gene expression programs in progenitors versus terminally differentiated cells and shows that a regulatory network involving myogenic regulatory factors, Snai1/2, miR-30a, andmiR-206 acts as a molecular switch that controls entry into myogenic differentiation.

TL;DR: It is proposed that, immunohistochemical screening for BAP1 should become routine in the histopathological work-up of uveal melanoma and indicates that loss of B AP1 may be particularly involved in the progression of uVEal melanomas to an aggressive, metastatic phenotype.

TL;DR: Three variants of multiplexed 3C sequencing are described, a 4C variant coupled to next-generation sequencing, allowing genome-scale detection of long-range interactions with candidate regions and an inexpensive, quick and efficient method that is ideal for the in-depth analysis of complex genetic loci.