G
Göksel Şener
Researcher at Marmara University
Publications - 291
Citations - 10047
Göksel Şener is an academic researcher from Marmara University. The author has contributed to research in topics: Malondialdehyde & Oxidative stress. The author has an hindex of 57, co-authored 263 publications receiving 9092 citations.
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Journal ArticleDOI
Melatonin prevents methotrexate-induced hepatorenal oxidative injury in rats.
TL;DR: The present study suggests that melatonin may be of therapeutic benefit when used with MTX and elucidates the role of free radicals in MTX‐induced toxicity and the protection by melatonin.
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Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.
TL;DR: Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities and showed maximum protection against pentylenetetrazole-induced convulsions in mice.
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Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion.
Göksel Şener,Osman Tosun,A. Özer Şehirli,Ayhan Kaçmaz,Serap Arbak,Yasemin Ersoy,Gül Ayanoğlu-Dülger +6 more
TL;DR: It is shown that Mel and NAC have beneficial effects against the I/R injury and due to their synergistic effects, when administered in combination, may have a more pronounced protective effects on the liver.
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β-glucan ameliorates methotrexate-induced oxidative organ injury via its antioxidant and immunomodulatory effects
TL;DR: The findings of the present study suggest that beta-glucan, through its antioxidant and immunoregulatory effects, may be of therapeutic value in alleviating the leukocyte apoptosis, oxidative tissue injury and thereby the intestinal and hepatorenal side effects of methotrexate treatment.
Journal ArticleDOI
Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death.
Mustafa Çetiner,Göksel Şener,A. Özer Şehirli,Emel Eksioglu-Demiralp,Feriha Ercan,Serap Sirvanci,Nursal Gedik,Sertac Akpulat,Tulay Tecimer,Berrak Ç. Yeğen +9 more
TL;DR: It appears that taurine protects against methotrexate-induced oxidant organ injury and inhibits leukocyte apoptosis and may be of therapeutic potential in alleviating the systemic side effects of chemotherapeutics.