G
Gonzalo Hortelano
Researcher at Nazarbayev University
Publications - 72
Citations - 2551
Gonzalo Hortelano is an academic researcher from Nazarbayev University. The author has contributed to research in topics: Mesenchymal stem cell & Genetic enhancement. The author has an hindex of 25, co-authored 67 publications receiving 2383 citations. Previous affiliations of Gonzalo Hortelano include McMaster University & Canadian Blood Services.
Papers
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Journal ArticleDOI
Cell encapsulation: promise and progress.
Gorka Orive,Rosa Maria Hernandez,Alicia R. Gascón,Riccardo Calafiore,Thomas Ming Swi Chang,Paul de Vos,Gonzalo Hortelano,David Hunkeler,Igor Lacík,A. M. James Shapiro,José Luis Pedraz +10 more
TL;DR: This commentary discusses the reasons for this, summarizes recent progress in the field and outlines what is needed to bring this technology closer to clinical application.
Journal ArticleDOI
History, challenges and perspectives of cell microencapsulation
Gorka Orive,R.M. Hernández,Alicia R. Gascón,Riccardo Calafiore,Thomas Ming Swi Chang,Paul de Vos,Gonzalo Hortelano,David Hunkeler,Igor Lacík,José Luis Pedraz +9 more
TL;DR: This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way, including capsule manufacture, properties and performance.
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Delivery of human factor IX in mice by encapsulated recombinant myoblasts: a novel approach towards allogeneic gene therapy of hemophilia B.
TL;DR: Allogeneic gene therapy strategy represents a potentially feasible alternative to autologous approaches for the treatment of hemophilia B by implanting encapsulated mouse myoblasts secreting human factor IX into allogeneic mice.
Journal ArticleDOI
Encapsulation of various recombinant mammalian cell types in different alginate microcapsules.
Michael Peirone,Colin J. D. Ross,Gonzalo Hortelano,Gonzalo Hortelano,John L. Brash,Patricia L. Chang +5 more
TL;DR: Results show that for culturing fibroblasts in a mechanically stable environment the classical calcium-linked microcapsules are adequate, however, where mechanical stability is a more critical requirement, the solid barium-linked gelled beads are more appropriate choices.
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Correction of the growth defect in dwarf mice with nonautologous microencapsulated myoblasts--an alternate approach to somatic gene therapy.
TL;DR: In this article, the authors proposed an alternative and potentially more cost-effective approach by implanting genetically modified "universal" cell lines to deliver desired gene products to nonautologous recipients.