Gopa Mitra

TL;DR: It is demonstrated that these sulfonamide drugs bind to the colchicine site of tubulin in a reversible manner and indicate that a mere alteration in the position of a single substituent chlorine on the indole scaffold has a great influence on the drug-tubulin binding thermodynamics.

TL;DR: The observations at low pH indicate that a reorganization of the intricate network of momentary long-range contacts in tau might have implication in its aggregation pathology, and nano-electrospray mass spectrometry coupled with ion mobility provides a direct insight into the ensemble of highly heterogeneous conformational families of tau at physiological pH.

TL;DR: The nanoparticle ferric pyrophosphate could be a promising food fortificant in combating iron deficiency anemia, while Fetuin-B, a negative acute phase protein, might be a potential candidate for detecting biological responses to the nanoparticle exposure in vivo.

TL;DR: This study investigated the effects of glutathionylation on quaternary structure of hemoglobin using hydrogen/deuterium exchange (H/DX) based mass spectrometry to understand structural perturbation on post-translational modification of proteins in solution phase.

TL;DR: The advantages of native mass spectrometry (MS) in analysing the atypical conformational dynamics of IDPs and recent advances made in the field are discussed.