G
Gordon Beck
Researcher at The Hertz Corporation
Publications - 7
Citations - 1382
Gordon Beck is an academic researcher from The Hertz Corporation. The author has contributed to research in topics: Intestinal absorption & Quantitative structure–activity relationship. The author has an hindex of 6, co-authored 7 publications receiving 1250 citations. Previous affiliations of Gordon Beck include Hoffmann-La Roche.
Papers
More filters
Journal ArticleDOI
Rate-limited steps of human oral absorption and QSAR studies.
Yuan H. Zhao,Michael H. Abraham,Joelle Le,Anne Hersey,Christopher N. Luscombe,Gordon Beck,Brad Sherborne,Ian Cooper +7 more
TL;DR: A nonlinear absorption model derived from first-order kinetics has been developed to identify the relationship between percentage of drug absorption and molecular descriptors and good relationships were found between absorption and Abraham descriptors or ClogP.
Journal ArticleDOI
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.
Yuan H. Zhao,Joelle Le,Michael H. Abraham,Anne Hersey,Peter J. Eddershaw,Chris N. Luscombe,Darko Boutina,Gordon Beck,Brad Sherborne,Ian Cooper,James Alexis Platts +10 more
TL;DR: The results show that Abraham descriptors can successfully predict human intestinal absorption if the human absorption data is carefully classified based on solubility and administration dose to humans.
Journal ArticleDOI
Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies.
Alim Khan,Mustapha Benboubetra,Pakeeza Sayyed,Keng Wooi Ng,Stephen P. Fox,Gordon Beck,Ibrahim F. Benter,Saghir Akhtar +7 more
TL;DR: It is suggested that biodegradable PLGA microspheres offer a method for improving the in vivo sustained delivery of gene silencing nucleic acids, and hence are worthy of further investigation as delivery systems for these macromolecules.
Journal ArticleDOI
Evaluation of rat intestinal absorption data and correlation with human intestinal absorption
Yuan H. Zhao,Michael H. Abraham,Joelle Le,Anne Hersey,Christopher N. Luscombe,Gordon Beck,Brad Sherborne,Ian Cooper +7 more
TL;DR: The result shows that the extent of absorption in these two species is similar and it is suggested that the absorption in rats could be used as an alternative method to human absorption in pre-clinical oral absorption studies.
Journal ArticleDOI
On the mechanism of human intestinal absorption.
Michael H. Abraham,Yuan H. Zhao,Joelle Le,Anne Hersey,Christopher N. Luscombe,Derek P. Reynolds,Gordon Beck,Brad Sherborne,Ian Cooper +8 more
TL;DR: It is suggested that the main step in the absorption process is diffusion through a stagnant mucus layer, together with transfer across the mucusmid R:membrane interface.