Y
Yuan H. Zhao
Researcher at University College London
Publications - 26
Citations - 2652
Yuan H. Zhao is an academic researcher from University College London. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 16, co-authored 18 publications receiving 2352 citations. Previous affiliations of Yuan H. Zhao include Hong Kong Environmental Protection Department.
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Journal ArticleDOI
Rate-limited steps of human oral absorption and QSAR studies.
Yuan H. Zhao,Michael H. Abraham,Joelle Le,Anne Hersey,Christopher N. Luscombe,Gordon Beck,Brad Sherborne,Ian Cooper +7 more
TL;DR: A nonlinear absorption model derived from first-order kinetics has been developed to identify the relationship between percentage of drug absorption and molecular descriptors and good relationships were found between absorption and Abraham descriptors or ClogP.
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Fast Calculation of van der Waals Volume as a Sum of Atomic and Bond Contributions and Its Application to Drug Compounds
TL;DR: A new method for calculating van der Waals volume has been developed, based on Bondi radii, and the results show that the van Der Waals volumes calculated from VABC are equivalent to the computer-calculated van derWaals volumes for organic compounds.
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Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors.
Yuan H. Zhao,Joelle Le,Michael H. Abraham,Anne Hersey,Peter J. Eddershaw,Chris N. Luscombe,Darko Boutina,Gordon Beck,Brad Sherborne,Ian Cooper,James Alexis Platts +10 more
TL;DR: The results show that Abraham descriptors can successfully predict human intestinal absorption if the human absorption data is carefully classified based on solubility and administration dose to humans.
Journal ArticleDOI
Correlation and prediction of a large blood–brain distribution data set—an LFER study
TL;DR: Log BB values are related to fundamental molecular properties, such as hydrogen bonding capability, polarity/polarisability and size, and it is concluded that such a model can predict log BB values with an accuracy of less than 0.35 log units.
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Application of hydrogen bonding calculations in property based drug design.
Michael H. Abraham,Adam Ibrahim,Andreas M. Zissimos,Yuan H. Zhao,John Comer,Derek P. Reynolds +5 more
TL;DR: The solvation equations can be interpreted to provide a qualitative chemical insight into biological partition and transport mechanisms and applications to blood-brain partition and human intestinal absorption are discussed.