G
Gour Chand Daskhan
Researcher at University of Alberta
Publications - 27
Citations - 409
Gour Chand Daskhan is an academic researcher from University of Alberta. The author has contributed to research in topics: SIGLEC & Glycan. The author has an hindex of 9, co-authored 23 publications receiving 167 citations. Previous affiliations of Gour Chand Daskhan include University of Grenoble & Joseph Fourier University.
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Journal ArticleDOI
Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2.
Linh Nguyen,Kelli A. McCord,Duong T Bui,Kim M. Bouwman,Elena N. Kitova,Mohamed Elaish,Mohamed Elaish,Dhanraj Kumawat,Gour Chand Daskhan,Ilhan Tomris,Ling Han,Pradeep Chopra,Tzu-Jing Yang,Steven Willows,Andrew Mason,Lara K. Mahal,Todd L. Lowary,Todd L. Lowary,Todd L. Lowary,Lori J. West,Shang-Te Danny Hsu,Shang-Te Danny Hsu,Tom C. Hobman,Stephen M. Tompkins,Stephen M. Tompkins,Geert-Jan Boons,Robert P. de Vries,Matthew S. Macauley,John S. Klassen +28 more
TL;DR: In this paper, the authors reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.
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A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands.
Emily Rodrigues,Jaesoo Jung,Heajin Park,Caleb Loo,Sepideh Soukhtehzari,Elena N. Kitova,Fahima Mozaneh,Gour Chand Daskhan,Edward N. Schmidt,Vivian Aghanya,Susmita Sarkar,Laura Streith,Chris D. St. Laurent,Linh Nguyen,Jean-Philippe Julien,Lori J. West,Karla C. Williams,John S. Klassen,Matthew S. Macauley +18 more
TL;DR: A new versatile set of Siglec-Fc proteins for glycan ligand detection, enabled through multimerization and avoiding Fc receptors, are described, revealing the abundance of their gly can ligands on host cells as self-associated molecular patterns.
Journal ArticleDOI
A multi-ligation strategy for the synthesis of heterofunctionalized glycosylated scaffolds
Baptiste Thomas,Baptiste Thomas,Michele Fiore,Michele Fiore,Gour Chand Daskhan,Gour Chand Daskhan,Nicolas Spinelli,Nicolas Spinelli,Olivier Renaudet,Olivier Renaudet,Olivier Renaudet +10 more
TL;DR: Well-defined heterofunctionalized glycosylated scaffolds with unprecedented molecular combinations have been prepared using up to five different bioorthogonal ligations, opening up chemical access to a diversity of biomolecular structures with high biological potential.
Journal ArticleDOI
Synthetic Strategies for Modified Glycosphingolipids and Their Design as Probes
TL;DR: This Review will discuss recent advances in chemical and chemoenzymatic synthesis of GSLs in conjunction with the use of these approaches to design new probes, and highlight examples of radionuclide, fluorophore, photoresponsive, and bioorthogonal tagged GSL probes.
Journal ArticleDOI
Aminooxylated Carbohydrates: Synthesis and Applications.
Carlo Pifferi,Gour Chand Daskhan,Michele Fiore,Tze Chieh Shiao,René Roy,Olivier Renaudet,Olivier Renaudet +6 more
TL;DR: This review provides the first in-depth overview covering several aspects related to the syntheses and applications of aminooxylated carbohydrates, including multivalent structures such as glycoclusters and glycodendrimers obtained through oxime ligation and their biological applications such as immunomodulators.