A
Andrew Mason
Researcher at University of Alberta
Publications - 391
Citations - 17672
Andrew Mason is an academic researcher from University of Alberta. The author has contributed to research in topics: Population & Primary biliary cirrhosis. The author has an hindex of 63, co-authored 360 publications receiving 15198 citations. Previous affiliations of Andrew Mason include University of Hawaii at Manoa & University of Glasgow.
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Journal ArticleDOI
Characterization of the Gut Microbiome Using 16S or Shotgun Metagenomics.
Juan Jovel,Jordan Patterson,Weiwei Wang,Naomi Hotte,Sandra O'Keefe,Troy Mitchel,Troy Perry,Dina Kao,Andrew Mason,Karen L. Madsen,Gane Ka-Shu Wong +10 more
TL;DR: The two main approaches for analyzing the microbiome, 16S ribosomal RNA gene amplicons and shotgun metagenomics, are illustrated with analyses of libraries designed to highlight their strengths and weaknesses and several methods for taxonomic classification of bacterial sequences are discussed.
Journal ArticleDOI
Association of diabetes mellitus and chronic hepatitis C virus infection.
Andrew Mason,Johnson Y.N. Lau,Nicole Hoang,Ke-Ping Qian,Graeme J.M. Alexander,Lizhe Xu,Linsheng Guo,Sheraj Jacob,Fredric Regenstein,Robert L. Zimmerman,James E. Everhart,Clive Wasserfall,Noel K. Maclaren,Robert P. Perrillo +13 more
TL;DR: A retrospective analysis of patients with chronic viral hepatitis and analyzed whether age, sex, race, hepatitis B virus (HBV) infection, HCV infection, and cirrhosis were independently associated with diabetes suggests a relatively strong association betweenHCV infection and diabetes.
Journal ArticleDOI
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
Gideon M. Hirschfield,Xiangdong Liu,Chun Xu,Yue Lu,Gang Xie,Yan Lu,Xiangjun Gu,Erin Walker,Kaiyan Jing,Brian D. Juran,Andrew Mason,Robert P. Myers,Kevork M. Peltekian,Cameron N. Ghent,Catalina Coltescu,Elizabeth J. Atkinson,Elizabeth J. Atkinson,E. Jenny Heathcote,Konstantinos N. Lazaridis,Christopher I. Amos,Katherine A. Siminovitch +20 more
TL;DR: Genomewide association data show significant associations between primary biliary cirrhosis and common genetic variants at the HLA class II, IL12A, and IL12RB2 loci and suggest that the interleukin-12 immunoregulatory signaling axis is relevant to the pathophysiology ofPrimary biliary Cirrhosis.
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The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis.
Zhaoyu Li,Luis B. Agellon,Theresa M. Allen,Masato Umeda,L D Jewell,Andrew Mason,Dennis E. Vance +6 more
TL;DR: Manipulation of PC/PE levels suggests that this ratio is a key regulator of cell membrane integrity and plays a role in the progression of steatosis into steatohepatitis and has clinical implications as patients with nonalcoholic steato hepatitis have a decreased ratio of PC to PE compared to control livers.
Journal ArticleDOI
Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid
Gideon M. Hirschfield,Andrew Mason,Velimir A. Luketic,Velimir A. Luketic,Keith D. Lindor,Keith D. Lindor,Stuart C. Gordon,Marlyn J. Mayo,Kris V. Kowdley,Catherine Vincent,Henry C. Bodhenheimer,Henry C. Bodhenheimer,Albert Parés,Michael Trauner,Hanns-Ulrich Marschall,Luciano Adorini,Cathi Sciacca,Tessa Beecher-Jones,E. Castelloe,O. Bohm,David Shapiro +20 more
TL;DR: Daily doses of OCA significantly reduced levels of ALP, γ-glutamyl transpeptidase, and alanine aminotransferase, compared with placebo, in patients with primary biliary cirrhosis who had inadequate responses to ursodeoxycholic acid.