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Showing papers by "Grace Y. Chen published in 2017"

Journal Article•DOI•
NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

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Sergey S. Seregin1, Natasha Golovchenko1, Bryan Schaf1, Jiachen Chen1, Nicholas A. Pudlo1, Jonathan S. Mitchell1, Nancy N. Baxter1, Lili Zhao1, Patrick D. Schloss1, Eric C. Martens1, Kathryn A. Eaton1, Grace Y. Chen1 •
University of Michigan1
25 Apr 2017-Cell Reports
TL;DR: It is shown that NLRP6 is important for suppressing the development of spontaneous colitis in the Il10-/- mice model of IBD and thatNLRP6 deficiency results in the enrichment of Akkermansia muciniphila.

252 citations

Journal Article•DOI•
Erratum: NLRP6 Protects Il10−/− Mice from Colitis by Limiting Colonization of Akkermansia muciniphila (Cell Reports (2017) 19(4) (733–745) (S2211124717304576) (10.1016/j.celrep.2017.03.080))

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Sergey S. Seregin, Natasha Golovchenko, Bryan Schaf, Jiachen Chen, Nicholas A. Pudlo, Jonathan S. Mitchell, Nancy N. Baxter, Lili Zhao, Patrick D. Schloss, Eric C. Martens, Kathryn A. Eaton, Grace Y. Chen 
06 Jun 2017-Cell Reports

54 citations

Journal Article•DOI•
NLRP6 function in inflammatory monocytes reduces susceptibility to chemically induced intestinal injury.

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Sergey S. Seregin1, Natasha Golovchenko1, Bryan Schaf1, Jiachen Chen1, Kathryn A. Eaton1, Grace Y. Chen1 •
University of Michigan1
01 Mar 2017-Mucosal Immunology
TL;DR: It is determined that NLRP6 expression is specifically upregulated in Ly6Chi inflammatory monocytes that infiltrate into the colon during dextran sulfate sodium (DSS)-induced inflammation, which reveals a previously unappreciated role forNLRP6 ininflammatory monocytes, which are recruited after DSS-induced intestinal injury to promote barrier function and limit bacteria-driven inflammation.

50 citations