G
Grace Y. Chen
Researcher at University of Michigan
Publications - 68
Citations - 12733
Grace Y. Chen is an academic researcher from University of Michigan. The author has contributed to research in topics: Gut flora & Innate immune system. The author has an hindex of 30, co-authored 58 publications receiving 10783 citations. Previous affiliations of Grace Y. Chen include New York University.
Papers
More filters
Journal ArticleDOI
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen,Gabriel Núñez +1 more
TL;DR: The triggers and receptor pathways that result in sterile inflammation and its impact on human health are reviewed.
Journal ArticleDOI
Role of the gut microbiota in immunity and inflammatory disease
TL;DR: Understanding the interaction of the microbiota with pathogens and the host might provide new insights into the pathogenesis of disease, as well as novel avenues for preventing and treating intestinal and systemic disorders.
Journal ArticleDOI
Control of pathogens and pathobionts by the gut microbiota.
TL;DR: The mechanisms that regulate the ability of the microbiota to restrain pathogen growth are complex and include competitive metabolic interactions, localization to intestinal niches and induction of host immune responses.
Journal ArticleDOI
The Prognostic Role of a Gene Signature from Tumorigenic Breast-Cancer Cells
Rui Liu,Xinhao Wang,Grace Y. Chen,Piero Dalerba,Piero Dalerba,Austin L. Gurney,Timothy Hoey,Gavin Sherlock,John Lewicki,Kerby Shedden,Michael F. Clarke,Michael F. Clarke +11 more
TL;DR: The gene-expression profile of CD44+CD24-/low tumorigenic breast-cancer cells with that of normal breast epithelium was compared to generate a 186-gene "invasiveness" gene signature (IGS), which was evaluated for its association with overall survival and metastasis-free survival in patients with breast cancer or other types of cancer.
Journal ArticleDOI
NOD-like receptors: role in innate immunity and inflammatory disease.
TL;DR: The NOD-like receptors are a specialized group of intracellular receptors that represent a key component of the host innate immune system and their ability to regulate nuclear factor-kappa B signaling, interleukin-1-beta production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.