Yun Gi Kim

TL;DR: The results link bacterial sensing by Nod proteins to the induction of autophagy and provide a functional link between Nod2 and ATG16L1, which are encoded by two of the most important genes associated with Crohn's disease.

TL;DR: The NOD-like receptors are a specialized group of intracellular receptors that represent a key component of the host innate immune system and their ability to regulate nuclear factor-kappa B signaling, interleukin-1-beta production, and cell death indicates that they are crucial to the pathogenesis of a variety of inflammatory human diseases.

TL;DR: It is shown that germ-free animals are unable to eradicate Citrobacter rodentium, a model for human infections with attaching and effacing bacteria, and pathogen colonization is controlled by bacterial virulence and through competition with metabolically related commensals.

TL;DR: Evidence for cytosolic delivery and sensing of bacterial molecules as a unifying model for caspase-1 activation and position pannexin-1 as a mechanistic link between bacterial stimuli and the cryopyrin inflammasome is provided.

TL;DR: It is shown that macrophages and mice lacking RICK are defective in their responses to Nod1 and Nod2 agonists but exhibit unimpaired responses to synthetic and highly purified TLR agonists.