Grace Y. Chen

TL;DR: It is determined that NLRP6 expression is specifically upregulated in Ly6Chi inflammatory monocytes that infiltrate into the colon during dextran sulfate sodium (DSS)-induced inflammation, which reveals a previously unappreciated role forNLRP6 ininflammatory monocytes, which are recruited after DSS-induced intestinal injury to promote barrier function and limit bacteria-driven inflammation.

TL;DR: A transition in the intestinal microflora is demonstrated accompanied by a dynamic change of its ability to stimulate different PRRs which control intestinal homeostasis, which is associated with a change from amicroflora rich in TLR4-stimulatory proteobacteria to one dominated by Bacteroidales and/or Clostridiales that poorly stimulateTLR4.

TL;DR: This review discusses host and microbiota-mediated metabolism of flavonoids and the potential mechanisms by which flavonoid can exert protective effects against colon tumorigenesis, including regulation of signaling pathways involved in apoptosis, cellular proliferation, and inflammation and modulation of the gut microbiome.

TL;DR: Studies in mice strongly suggest that the gut microbiota can modulate susceptibility to CRC, and therefore may serve as both biomarkers and therapeutic targets.

TL;DR: An important functional role is found for MAZ in the inflammatory progression of colon cancer through regulation of STAT3 signaling and it is suggested that MAZ is a potential therapeutic target to dampenSTAT3 signaling in colon cancer.