Gracia Merino

TL;DR: The multidrug transporter BCRP is strongly induced in the mammary gland of mice, cows and humans during lactation and it is responsible for the active secretion of clinically and toxicologically important substrates such as the dietary carcinogen PhIP, the anticancer drug topotecan and the antiulcerative cimetidine into mouse milk.

TL;DR: The H2-receptor antagonist drug cimetidine was identified as a novel efficiently transported substrate for human BCRP and mouse Bcrp1, and none of the tested endogenous steroids or synthetic glucocorticoids or digoxin, however, were transported substrates of B CRP.

TL;DR: It is demonstrated that BCRP is responsible for pumping riboflavin (vitamin B2) into milk, thus supplying the young with this important nutrient and establishes the principle that an ABC transporter can transport a vitamin into milk and raises the possibility that other vitamins and nutrients are likewise secreted into milk by ABC transporters.

TL;DR: It is concluded that Bcrp1 is an important determinant for the bioavailability of nitrofurantoin and the main mechanism involved in its hepatobiliary excretion and secretion into the milk.

TL;DR: It is concluded that Bcrp1 is one of the determinants for the bioavailability of fluoroquinolones and their secretion into the milk.