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Petr Pavek

Researcher at Charles University in Prague

Publications -  149
Citations -  5354

Petr Pavek is an academic researcher from Charles University in Prague. The author has contributed to research in topics: Pregnane X receptor & Nuclear receptor. The author has an hindex of 37, co-authored 140 publications receiving 4557 citations. Previous affiliations of Petr Pavek include Palacký University, Olomouc & Slovak Academy of Sciences.

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Journal ArticleDOI

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

Petr Pavek, +5 more
- 19 Jan 2012 - 
TL;DR: It is found that SHP mRNA is not systematically down-regulated in hepatocyte in culture after 24 h treatment with rifampicin, and the phenomenon is unlikely critical for PXR-mediated induction of its target genes.
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Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.

Petr Pavek, +1 more
- 31 Jan 2008 - 
TL;DR: The goal of this review is to critically examine current understanding of molecular mechanisms involved in induction of xenobiotic metabolizing CYP genes of human families CYP1, CYP2 and CYP3 by exogenous chemicals in extrahepatic tissues.
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Human breast cancer resistance protein : Interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine

Petr Pavek, +6 more
- 01 Jan 2005 - 
TL;DR: The H2-receptor antagonist drug cimetidine was identified as a novel efficiently transported substrate for human BCRP and mouse Bcrp1, and none of the tested endogenous steroids or synthetic glucocorticoids or digoxin, however, were transported substrates of B CRP.
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Breast cancer resistance protein (BCRP/ABCG2)

Frantisek Staud, +1 more
- 01 Apr 2005 - 
TL;DR: Breast cancer resistance protein (BCRP) was identified 7 years ago as the most recent member of ABC drug efflux membrane transporters and is responsible for the "side population" phenotype of stem cells and seems to play a significant role in protection against hypoxia.
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Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

Lukas Cerveny, +8 more
- 01 Jul 2007 - 
TL;DR: The results demonstrate that VPA has potential to up-regulate CYP3A4 and MDR1 through direct activation of CAR and/or PXR pathways and suggest that Vpa synergistically augments the effect of rifampicin in transactivation of CYP 3A4 in primary human hepatocytes.