G
Graham C. Walker
Researcher at Massachusetts Institute of Technology
Publications - 386
Citations - 39252
Graham C. Walker is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Sinorhizobium meliloti & DNA polymerase. The author has an hindex of 93, co-authored 381 publications receiving 36875 citations. Previous affiliations of Graham C. Walker include Norwich Research Park & University of California, Santa Cruz.
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Journal ArticleDOI
Mutations altering heat shock specific subunit of RNA polymerase suppress major cellular defects of E. coli mutants lacking the DnaK chaperone.
Bernd Bukau,Graham C. Walker +1 more
TL;DR: The findings suggest that the physiologically most significant function of DnaK in the metabolism of unstressed cells is its function in heat shock gene regulation.
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Y-family DNA polymerases in Escherichia coli
TL;DR: Genetic and biochemical studies have revealed that Escherichia coli genes umuC+ and its homolog dinB+ encode novel DNA polymerases with the ability to catalyze synthesis past DNA lesions that otherwise stall replication--a process termed translesion synthesis (TLS).
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Characterization of a Novel Pyranopyridine Inhibitor of the AcrAB Efflux Pump of Escherichia coli
Timothy J. Opperman,Steven M. Kwasny,Hong-Suk Kim,Son T. Nguyen,Chad Houseweart,Sanjay D'Souza,Graham C. Walker,Norton P. Peet,Hiroshi Nikaido,Terry L. Bowlin +9 more
TL;DR: MBX2319 is a potent EPI with possible utility as an adjunctive therapeutic agent for the treatment of infections caused by Gram-negative pathogens and was broadly active against Enterobacteriaceae species and Pseudomonas aeruginosa.
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Family of glycosyl transferases needed for the synthesis of succinoglycan by Rhizobium meliloti.
TL;DR: The sequence of a family of glycosyl transferases required for the synthesis of succinoglycan is presented and their functions are discussed to discuss their functions.
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Rhizobium meliloti exopolysaccharides: Synthesis and symbiotic function
TL;DR: Small quantities of low-molecular-weight EPS are sufficient to mediate successful invasion by R. meliloti-M.