G
Graziella M. De Montis
Researcher at University of Cagliari
Publications - 15
Citations - 553
Graziella M. De Montis is an academic researcher from University of Cagliari. The author has contributed to research in topics: Dopaminergic & Apomorphine. The author has an hindex of 9, co-authored 15 publications receiving 552 citations.
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The striatal dopaminergic function is mediated by the inhibition of a nigral, non-dopaminergic neuronal system via a strio-nigral GABAergic pathway.
TL;DR: The contralateral turning and the stereotypes induced by the acute, intranigral administration of muscimol were very similar to the chronic effects elicited by intranIGral kainic acid (k.a.) observed from 24 h to several days after treatment.
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Possible role of dopamine D1 receptor in the behavioural supersensitivity to dopamine agonists induced by chronic treatment with antidepressants.
TL;DR: The results indicate that chronic treatment with ADs potentiates the behavioural responses mediated by the stimulation of postsynaptic D2 receptors in the mesolimbic system and suggest that this behavioural supersensitivity is due to enhanced neurotransmission at the D1 receptor level.
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Intranigral kainic acid: evidence for nigral non-dopaminergic neurons controlling posture and behavior in a manner opposite to the dopaminergic ones.
Maria C. Olianas,Graziella M. De Montis,Alberto Concu,Alessandro Tagliamonte,Gaetano Di Chiara +4 more
TL;DR: The unilateral, intranigral administration of kainic acid produced a syndrome characterized by early sequelae of contra- and ipsilateral circling and by a chronic contralateral turning associated with moderate loss of neurons in the pars reticulata that may be related to dopaminergic nigro-neostriatal neuron stimulation.
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Central dopaminergic transmission is selectively increased in the limbic system of rats chronically exposed to antidepressants.
Graziella M. De Montis,Paola Devoto,Gian Luigi Gessa,Domenico Meloni,Anna Porcella,Pierluigi Saba,Gino Serra,Alessandro Tagliamonte +7 more
TL;DR: Repeated electroconvulsive shock (ECS) exposure produced a decrease of [3H]SCH 23390 binding sites and a reduced response of adenylate cyclase activity to dopamine D-1 receptor stimulation in the rat limbic area analogous to that previously observed in rats chronically treated with imipramine.
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Evidence that a nigral gabaergic-chrolinergic balance controls posture
Graziella M. De Montis,Maria C. Olianas,Gino Serra,Alessandro Tagliamonte,Jørgn Scheel-Krüger +4 more
TL;DR: It is concluded that the muscarinic receptors present in the s.n. pars reticulata play a role in the control of posture opposite to that of the nigral GABA receptors.