G
Grazyna Debska-Vielhaber
Researcher at Otto-von-Guericke University Magdeburg
Publications - 35
Citations - 1017
Grazyna Debska-Vielhaber is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Mitochondrion & Respiratory chain. The author has an hindex of 18, co-authored 33 publications receiving 822 citations. Previous affiliations of Grazyna Debska-Vielhaber include University of Bonn & Leibniz Institute for Neurobiology.
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Journal ArticleDOI
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.
Alexei P. Kudin,Grazyna Debska-Vielhaber,Stefan Vielhaber,Christian E. Elger,Wolfram S. Kunz +4 more
TL;DR: For the antiepileptic drug (AED) topiramate (TPM), neuroprotective effects have been reported in models of focal cerebral ischemia and experimental status epilepticus, but the putative mechanism of action has remained elusive.
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Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion
Stefan Vielhaber,Grazyna Debska-Vielhaber,Viktoriya Peeva,Susanne Schoeler,Alexei P. Kudin,Irina Minin,Stefanie Schreiber,Reinhard Dengler,Katja Kollewe,Werner Zuschratter,Cornelia Kornblum,Gábor Zsurka,Wolfram S. Kunz +12 more
TL;DR: The findings corroborate the hypothesis that MFN2 mutations alter mitochondrial oxidative phosphorylation by affecting mtDNA replication by deleting essential parts of mtDNA required for replication.
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Subfield‐specific Loss of Hippocampal N‐acetyl Aspartate in Temporal Lobe Epilepsy
Stefan Vielhaber,Heiko G. Niessen,Grazyna Debska-Vielhaber,Alexei P. Kudin,Jörg Wellmer,Jörn Kaufmann,Mircea Ariel Schönfeld,Robert Fendrich,Wieland Willker,Dieter Leibfritz,Johannes Schramm,Christian E. Elger,Hans-Jochen Heinze,Wolfram S. Kunz +13 more
TL;DR: In patients with mesial temporal lobe epilepsy (MTLE), it remains an unresolved issue whether the interictal decrease in N‐acetyl aspartate (NAA) detected by proton magnetic resonance spectroscopy (1H‐MRS) reflects the epilepsy‐associated loss of hippocampal pyramidal neurons or metabolic dysfunction.
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Characterization of superoxide production sites in isolated rat brain and skeletal muscle mitochondria
TL;DR: In this paper, the authors quantified the superoxide and H 2 O 2 production rates of intact rat brain and skeletal muscle mitochondria under condition of oxygen saturation applying p -hydroxyphenylacetate as fluorescent probe for H 2 o 2 generation and hydroethidine as probe for superoxide formation.
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Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Heiko G. Niessen,Grazyna Debska-Vielhaber,Kerstin Sander,Frank Angenstein,Frank Angenstein,Albert C. Ludolph,Liane Hilfert,Wieland Willker,Dieter Leibfritz,Hans-Jochen Heinze,Wolfram S. Kunz,Stefan Vielhaber +11 more
TL;DR: High‐resolution 1H‐MRS allows a sensitive spatial and temporal metabolite profiling in the presymptomatic phase of ALS even before significant neuronal cell loss occurs.