Green Ahn

TL;DR: The results establish a modular strategy for directing secreted and membrane proteins for lysosomal degradation, with broad implications for biochemical research and for therapeutics.

TL;DR: An αHER2 antibody–neuraminidase conjugate, which selectively targets the removal of sialic acids from glycans on breast cancer cells, bypasses a glycoimmune checkpoint and enhances tumor cell killing by the host immune system.

TL;DR: GalNAc-Lysosome-targeting chimeras (LYTACs) as discussed by the authors were developed to degrade extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR).

TL;DR: A comprehensive overview of targeted protein degradation (TPD) platforms that degrade extracellular proteins via outside-in approaches can be found in this article, with a focus on the recent development of Lysosome-targeting chimeras (LYTACs).

TL;DR: A bright solvatochromic dye trehalose conjugate that specifically detects Mycobacterium tuberculosis (Mtb) in minutes is reported on, which has exceptionally favorable properties for Mtb detection.