K
Kayvon Pedram
Researcher at Stanford University
Publications - 27
Citations - 1968
Kayvon Pedram is an academic researcher from Stanford University. The author has contributed to research in topics: Mucin & Glycosylation. The author has an hindex of 14, co-authored 22 publications receiving 1017 citations. Previous affiliations of Kayvon Pedram include Massachusetts Institute of Technology & University of California, Los Angeles.
Papers
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Journal ArticleDOI
Lysosome-targeting chimaeras for degradation of extracellular proteins.
Steven M. Banik,Kayvon Pedram,Simon Wisnovsky,Green Ahn,Nicholas M. Riley,Carolyn R. Bertozzi,Carolyn R. Bertozzi +6 more
TL;DR: The results establish a modular strategy for directing secreted and membrane proteins for lysosomal degradation, with broad implications for biochemical research and for therapeutics.
Journal ArticleDOI
Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2.
Victoria Hung,Namrata D. Udeshi,Stephanie S Lam,Ken H. Loh,Kurt James Cox,Kayvon Pedram,Steven A. Carr,Alice Y. Ting,Alice Y. Ting +8 more
TL;DR: This protocol describes the generation of an appropriate APEX2 fusion construct, proteomic sample preparation, and mass spectrometric data acquisition and analysis, and a two-state stable isotope labeling by amino acids in cell culture (SILAC) protocol is used for proteomic mapping of membrane-enclosed cellular compartments.
Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2
Victoria Hung,Namrata D. Udeshi,Stephanie S Lam,Ken H. Loh,Kurt James Cox,Kayvon Pedram,Steven A. Carr,Alice Y. Ting,Alice Y. Ting +8 more
TL;DR: In this article, an engineered peroxidase, APEX2, is genetically targeted to a cellular region of interest, and upon the addition of hydrogen peroxide for 1 min to cells preloaded with a biotin-phenol substrate, the peroxide generates biotinphenoxyl radicals that covalently tag proximal endogenous proteins.
Journal ArticleDOI
Small RNAs are modified with N-glycans and displayed on the surface of living cells.
Ryan A. Flynn,Kayvon Pedram,Stacy A. Malaker,Pedro J. Batista,Benjamin A. H. Smith,Alex G. Johnson,Benson M. George,Karim Majzoub,Peter W. Villalta,Jan E. Carette,Carolyn R. Bertozzi +10 more
TL;DR: Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all domains of life as mentioned in this paper, and RNA is used as a third scaffold for glycosylation.
Journal ArticleDOI
Physical Principles of Membrane Shape Regulation by the Glycocalyx
Carolyn R. Shurer,Joe Chin-Hun Kuo,LaDeidra Monet Roberts,Jay G. Gandhi,Marshall J. Colville,Thais A. Enoki,Hao Pan,Jin Su,Jade M. Noble,Michael J. Hollander,John P. O’Donnell,Rose Yin,Kayvon Pedram,Leonhard Möckl,Lena F. Kourkoutis,W. E. Moerner,Carolyn R. Bertozzi,Gerald W. Feigenson,Heidi L. Reesink,Matthew J. Paszek +19 more
TL;DR: A synergy between shape-generating processes in the cell interior and the external organization and composition of the cell-surface glycocalyx is reported, suggesting a fundamental role for the glycocalypse in regulating curved membrane features that serve in communication between cells and with the extracellular matrix.